A pair of Purdue University researchers from the College of Pharmacy and the College of Veterinary Medicine developed small molecules to combat deadly, drug-resistant enterococcus.
Anti-inflammatory substances based on components of human cells could one day improve treatment in patients. Researchers at the Institute of Pharmacy at Martin Luther University Halle-Wittenberg (MLU) have developed a method for producing those substances with controlled quality. Since the body does not recognise them as foreign substances, they offer advantages over anti-inflammatory drugs such as ibuprofen or diclofenac. The results were published in the "European Journal of Pharmaceutical Sciences".
Computer-designed miniproteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19. The lead antiviral candidate rivals the best-known SARS-CoV-2 monoclonal antibodies in its protective actions. The synthetic antiviral candidates were designed to prevent infection by interfering with the mechanism that coronaviruses use to break into and enter cells.
Imaging artifacts discovered in high-resolution electron microscopes may impact development of next-generation electronic devices.
Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma.
In rodents with type 2 diabetes, a single surgical injection of a protein called fibroblast growth factor 1 can restore blood sugar levels to normal for weeks or months. Yet how this growth factor acts in the brain to generate this lasting benefit has been poorly understood. Clarifying how this occurs might lead to more effective diabetes treatments that tap into the brain's inherent potential to ameliorate the condition.
Looking closely at the chemical process that transforms methane into useful products could help unveil more efficient ways to use natural gas.
A class of drugs used for many conditions, including allergies, colds, high blood pressure and depression, may be associated with an increased risk of developing mild thinking and memory problems, particularly in people who have genetic risk factors for Alzheimer's disease or markers of this condition, according to a study published in the Sept. 2, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Scientists have taken a significant step forward in the search to find effective new drug candidates for the treatment of Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease.
Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics / study in 'Nature Communications'