POSTECH-UNIST joint research team finds ways to control the surface texture of nanostructures.
Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers at Purdue created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment.
A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk.
In a preclinical study led by the University of South Florida, researchers identified and characterized 18 new compounds (agonists) that activate bitter taste receptor subtype TAS2R5 to promote relaxation of human airway smooth muscle cells. The cross-disciplinary team found 1,10 phenanthroline-5,6-dione (T5-8 for short) was 1,000 times more potent than some of the other bronchodilator agonists tested, and it demonstrated marked effectiveness in human airway smooth muscle cells grown in the laboratory.
Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that a combination of an LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke than a single drug.
Russian scientists from Kaliningrad and St. Petersburg have synthesized nitrogen-containing cyclic compounds that differ only in the relative position of side substituents. They are analogs of pesticides which are toxic and carcinogenic to humans, but the modifications allowed turning them into a powerful weapon against bacteria resistant to most antibiotics.
As COVID-19 vaccines are becoming available, physicians and other health care professionals must do the hard work of making sure sufficient numbers of people are vaccinated to end the pandemic.
The January edition of SLAS Discovery features the cover article, "Cryo-EM: The Resolution Revolution and Drug Discovery" by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca.
This study revealed the development of a novel iridium based catalyst. The catalyst is capable of accessing the carbocation intermediates of the reaction to achieve an unprecedented level of regioselectivity (>95%) and enantioselectivity (98%). This technology will have far-reaching implications in synthetic, organic, and pharmaceutical chemistry.
The COVID-19 pandemic has disrupted health care delivery in the United State, and researchers in this study examined changes in total US retail pharmacy sales and sales of buprenorphine products with a US Food and Drug Administration-approved indication for treatment of opioid use disorder.