A team including researchers from Osaka University has developed a surface-enhanced Raman scattering (SERS) microscopy technique for tracking small molecules in live cells. The technique uses gold nanoparticles to boost the signal from alkyne group tags attached to the molecules. The alkyne group has a minimal effect on the drug molecule behavior and provides a signal that can be easily distinguished from the cell background. Their technique is expected to be useful in drug discovery.
Purdue University innovators are using machine learning models to create new options for drug discovery pipelines. Purdue innovators have introduced chemical reactivity flowcharts to help chemists interpret reaction outcomes using statistically robust machine learning models trained on a small number of reactions.
An experimental Alzheimer's disease treatment is proving effective at treating some of the most persistent, life-threatening antibiotic-resistant bacteria. Researchers from The University of Queensland, The University of Melbourne and Griffith University have discovered that the drug called PBT2 is effective at disrupting and killing a class of bacteria - known as Gram-negative bacteria - that cause infections such as pneumonia, bloodstream infections and meningitis.
Scientists from the Tokyo University of Science have made a breakthrough in the development of potential drugs that can kill cancer cells. They have discovered a method of synthesizing organic compounds that are four times more fatal to cancer cells and leave non-cancerous cells unharmed. Published in the American Chemical Society Omega, their research can assist in the creation of new anticancer drugs with minimal side effects.
This could be used in treating skin diseases such as atopic dermatitis and epidermolysis bullosa, as well as in the fields of cosmetics and nutrition
Darwin's theory of evolution should be expanded to include consideration of a DNA stability "energy code" - so-called "molecular Darwinism" - to further account for the long-term survival of species' characteristics on Earth, according to Rutgers scientists.
Melatonin is used as a dietary supplement to promote sleep and get over jet lag, but nobody really understands how it works in the brain. Now, researchers at UConn Health show that melatonin helps worms sleep, too, and they suspect they've identified what it does in us.
A polymeric nanomicelle that effectively delivers to glioblastoma (GBM) was developed.
A new treatment option for lung fibrosis is being developed by Purdue University scientists. People with idiopathic pulmonary fibrosis (IPF) have a life expectancy of less than five years. The Purdue team has developed two targeted therapies for people with IPF.
The journal CrystEngComm has published a special issue to mark the Cambridge Structural Database (CSD) reaching 1 million structures, with 33 papers that highlight the breadth of applications made possible with this data.