This randomized clinical trial compares the effects of three doses of bamlanivimab monotherapy (700 vs 2,800 vs 7,000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate COVID-19.
This is a non-coding section of the RNA, which means that it is not translated into a protein, but it is likely key to the virus's replication.
Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common structural features across bacteria from different geographic locations, even though the ants share a common ancestor. Now, researchers report in ACS Central Science they have identified the first shared antifungal compound among many of these bacteria across Brazil. The compound could someday have medical applications.
Researchers captured and comparted hi-res images of ribosome structures from sensitive and resistant bacteria and report that a water molecule needed for antibiotic binding was not present in the ribosomes from the drug-resistant bugs.
Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) have developed a method named D2O-probed CANcer Susceptibility Test Ramanometry (D2O-CANST-R) to see, at single-cell/organelle level, how pharmaceuticals induce cancer cell death and how cancer cells adapt.
Scientists have discovered a molecule that can selectively kill cells of a hard-to-treat subtype of breast cancer, which could lead to a new therapy.
Kanazawa University scientists use computer simulations of charged molecules to help improve the accuracy of mass spectrometers. By understanding the collisions between ions that reduce excess charges, this work may lead to more sensitive radiocarbon dating and medical testing.
'What goes in, must come out' is a familiar refrain. It is especially pertinent to the challenges facing UBC researchers who are investigating methods to remove chemicals and pharmaceuticals from public water systems. Cleaning products, organic dyes and pharmaceuticals are finding their ways into water bodies with wide-ranging negative implications to health and the environment, explains Dr. Mohammad Arjmand, an assistant professor of mechanical engineering at UBC Okanagan.
A new method to synthesize vaccines safely and quickly should see much faster pre-clinical testing to pursue strategies to combat novel pathogens, something the COVID pandemic has shown is necessary.
Naltrexone, used either alone or together with disulfiram or acamprosate, is associated with a decreased risk of hospitalization due to alcohol use disorder (AUD) when compared with non-use of AUD drugs, a new register-based study shows.