Scientists identify how a nonfunctioning CASK gene creates chaos in the brain.
Developing a new strategy to selectively deliver therapies to the brain
Most neurons are created during embryonic development and have no "backup" after birth. Researchers have generally believed that their survival is determined nearly extrinsically, or by outside forces, such as the tissues and cells that neurons supply with nerve cells. A research team led by Sika Zheng, a biomedical scientist at the University of California, Riverside, has challenged this notion and reports the continuous survival of neurons is also intrinsically programmed during development.
A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer's disease. The results show the inhibition of the enzyme soluble epoxide hydrolase (sEH) in murine models with the disease reduces the neuroinflammatory process, improving the endogen response of the organism and reducing the neuronal damage and death that cause this type of dementia.
Research conducted at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine found that spinal cord injuries in mice cause an acquired bone marrow failure syndrome that may contribute to chronic immune dysfunction. "We also found that it's possible to overcome certain aspects of spinal cord injury-induced bone marrow failure. This could have an immediate impact on people affected by spinal cord injury," said lead author Phillip Popovich.
The brain never processes the same information in the same way. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) have found out why this is the case and how it works. A decisive role plays a critical state of the neuronal networks.
Researchers have developed a new approach to compare changes in neural communication using electroencephalography and functional magnetic resonance imaging simultaneously. The approach allows them to assess the association between the two measurements and better understand neural connectivity changes over time.
Do you remember where you were when you first heard that two planes had crashed into New York's Twin Towers? Or where you had your first kiss? Our brains are wired to retain information that relates to the context in which highly significant events occurred. This mechanism also underlies drug addiction and is the reason why hanging out in an environment or with people associated with memories of drug use often leads to relapse.
New research led by King's College London has found that measuring levels of inflammation and stress-response in the blood may provide useful information to show which patients with depression will or will not respond to treatment with antidepressants.
Researchers from MIT and the Broad Institute of MIT and Harvard have mapped the thalamic reticular nucleus in unprecedented detail, revealing that the region contains two distinct subnetworks of neurons with different functions. The findings could offer researchers much more specific targets for designing drugs that could alleviate attention deficits, sleep disruption, and sensory hypersensitivity.