Aconite root is used in East Asian traditional medicines to treat pain. Since its toxicity, it is used after heat-processing for detoxifying. The present study revealed that processed aconite root could relief neuropathic pain in murine peripheral neuropathy model induced by oxaliplatin, paclitaxel, or partial ligation of the sciatic nerve (Seltzer model), and identified that its active ingredient is not benzoylmesaconine, a degraded compound of toxic mesaconitine, but neoline, a stable compound by detoxifying heat-processing.
Traces of neonicotinoid pesticides can impair a flying insect's ability to spot predators and avoid collisions with objects in their path.
Little is known about the potential health effects of JUUL e-cigarette products that have recently risen in popularity, especially among adolescents. The FDA has a growing concern about this uptick in their use because these electronic cigarettes deliver nicotine. A research team led by UC Riverside and Portland State University has now found that nicotine concentrations are higher in JUUL electronic cigarettes than in any of the many other electronic cigarette products the team analyzed.
New peer reviewed research commissioned by Imperial Brands was undertaken to investigate the potential adverse effects of blu e-vapor on human airway tissue, compared with conventional cigarette smoke. In the in-vitro study, the impact of e-vapor -- from both flavoured and unflavoured e-liquid - on human airway tissue was similar to fresh air. In contrast, exposure to conventional cigarette smoke resulted in a significant and rapid decrease in lung tissue viability under the test conditions.
A team of scientists headed by Maik Behrens from the Leibniz-Institute for Food Systems Biology at the Technical University of Munich has identified the receptor responsible for the bitter taste of various salts. These include medically used Epsom salt. The discovery helps to elucidate the physiological mechanisms by which Epsom salt affects the heart or gut. The team has now published the findings in the journal Biochemical and Biophysical Research Communications (DOI: 10.1016/j.bbrc.2019.03.139).
Tests of Europe's rivers and canals have revealed more than 100 pesticides -- including 24 that are not licensed for use in the EU.
Measurements of hazardous air pollutant concentrations near oil and natural gas extraction sites have generally failed to capture levels above standard health benchmarks; yet, the majority of studies continue to find poor health outcomes increasing as distance from these operations decreases.
Michigan State University scientists have linked a common food preservative to an altered immune response that possibly hinders flu vaccines.
TTI has created a heat map showing the relationship between traffic-related air pollution and childhood asthma. Around 6 million children in the United States are affected by asthma, making the condition the most common chronic lung disease in children. These interactive visualizations illustrate the impact of traffic related air pollution on the burden of incident childhood asthma in the contiguous United States in 2000 and 2010.
Ground-breaking work by university experts in Tennessee, Texas and Swansea is helping develop a better understanding of the growing threat posed by antifungal drug resistance. Invasive aspergillosis is a devastating disease caused by breathing in small airborne spores of the fungus Aspergillus fumigatus and it is a condition where drug resistance has been encountered. They have just released a paper revealing how they have been able to identify a previously uncharacterized genetic mutation in clinical isolates that leads to resistance.