Sleeping sickness-causing parasites contain an unusual protein synthesis machinery. A team of researchers from ETH Zurich and the University of Berne resolved its very special structure for the first time.
Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now identified three new molecular drug targets in Naegleria fowleri and a number of drugs that are able to inhibit the amoeba's growth in a laboratory dish. Several of these drugs are already approved by the US Food and Drug Administration for other uses, such as antifungal agents, the breast cancer drug tamoxifen and antidepressant Prozac.
The parasitic disease leishmaniasis is spread to humans through the bites of sandflies, and is endemic in a number of countries, including Brazil. Despite control efforts, the incidence of visceral leishmaniasis -- the most severe form of the disease -- rose in Brazil between 1990 and 2016, researchers have reported in PLOS Neglected Tropical Diseases.
In an unexpected research finding infections with the intestinal parasite, Cryptosporidium parvum, worsened in mice that had been given a probiotic. The research was published in Applied and Environmental Microbiology, a journal of the American Society for Microbiology.
A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting. But if a drug-resistant strain does become established, that same competition drives the spread of resistance faster, under strong selection from antimalarial drug use.
EPFL scientists have deciphered mechanisms that help the cholera bacterium to survive grazing predators in aquatic environments.
Leishmania is a microorganism threatening the health of over 500 million people at risk of crossing its path. Although leishmaniasis, the disease caused by the parasite, has been on the radar of scientists for a long time, the quest for affordable and effective treatment continues. INRS professors Albert Descoteaux and Steven LaPlante have developed a new, cost-effective strategy to rapidly identify molecules capable of eliminating Leishmania.
Water quality in rivers and dams is decaying all over the world, and metal pollution is a major factor. Meanwhile, freshwater resources are very limited. A tiny fish louse shows promise as a sensitive early indicator for metal pollution in freshwater.
James Cook University scientists in Australia have discovered that shrimp help heal injured fish.
Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a discovery by an interdisciplinary research team at the University of California, Riverside. The research, done on a mouse model, identifies cell signaling pathways associated with the endocannabinoid system that could be targeted to develop therapeutic treatments aimed at eliminating worm infection or improving infection outcomes.