Researchers discover new cell population that can help in regenerative processes.
Human cells have a sophisticated regulatory system at their disposal: labeling proteins with the small molecule ubiquitin. In a first, a team from the Technical University of Munich (TUM) has succeeded in marking proteins with ubiquitin in a targeted manner, in test tubes as well as in living cells. The procedure opens the door to exploring the inner workings of this vital regulatory system.
Current techniques to assess plant chemical defense require large amounts of both time and plant tissue. Researchers have developed a new, high-throughput, cost-effective method that requires only a fraction of the traditional tissue sample weight and makes it possible to investigate multiple compounds at once, look at local vs. systemic responses, and quantify environmental and genetic variation.
By focusing light down to the size of an atom, scientists at the University of California, Irvine have produced the first images of a molecule's normal modes of vibration -- the internal motions that drive the chemistry of all things, including the function of living cells.
The central goal of nanotechnology is the manipulation of materials on an atomic or molecular scale, especially to build microscopic devices or structures. Three-dimensional cages are one of the most important targets, both for their simplicity and their application as drug carriers for medicine. DNA nanotechnology uses DNA molecules as programmable "Legos" to assemble structures with a control not possible with other molecules.
Metastatic ovarian, prostate and breast cancers are notoriously difficult to treat and often deadly. Now, Salk Institute researchers have revealed a new role for the CDK12 protein. The findings were published in the print version of Genes & Development on April 1, 2019.
In one of the largest and most diverse leaf microbe studies to date, the team monitored the active bacteria on the leaves of 300 diverse lines of corn growing in a common environment. They were especially interested to see how corn genes affected bacteria and found there was little relationship between the two--in fact, the bacteria were much more affected by the environment, although genetics still had a small role.
A highly drug-resistant bacteria common in hospitals, Klebsiella pneumoniae, represents a significant antimicrobial resistance threat and should be monitored globally, say UCL researchers. The warning follows new genetic analyses revealing how K. pneumoniae are able to quickly evolve to change their genetic makeup. This has implications for understanding how several species of bacteria -- called Enterobacteriaceae -- can rapidly adapt to essentially any antibiotic currently used in treatment.
Researchers at Sanford Burnham Prebys have demonstrated a causal link between the gut microbiome and the immune system's ability to fight cancer.
A new understanding of cell migration may eventually help in the treatment of neurodegenerative diseases -- and even allow children to 'get out of their wheelchairs and live an enhanced quality of life.'