Article signed by researchers affiliated with institutions in the US, UK, Ghana and Brazil highlights recent progress in diagnosis and treatment but warns that more screening of newborns is needed.
Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite's life cycle and prevent the development of malaria.
One in five people (22%) living in an area affected by conflict has depression, anxiety, post-traumatic stress disorder, bipolar disorder or schizophrenia, and about 9% of conflict-affected populations have a moderate to severe mental health condition, according to an analysis of 129 studies published in The Lancet. The figures are substantially higher than the global estimate for these mental health conditions in the general population, which stands at one in 14 people (as shown in the Lancet infographic).
Viruses, spread through mosquito bites, cause human illnesses such as dengue fever, Zika and yellow fever. A new control technique harnesses a naturally occurring bacterium called Wolbachia that blocks replication of viruses and breaks the cycle of mosquito-borne disease, according to an international team of researchers.
New research shows the expanded risk of dengue virus infection through 2080, with detailed maps for 2020, 2050 and 2080. The paper is the first to use the projected spread of mosquitoes that carry the virus to inform the models. Unlike some past models, the results do not predict a large expansion of risk in Europe.
A team from Nanjing University in China reported that the small silencing RNA sequences against HBsAg generated in edible lettuce (Lactuca sativa L.) can specifically bind and inhibit gene expression in p21-HBsAg knock-in transgenic mice and improve liver injury at a relatively low level when compared to synthetic siRNAs. This work may also be helpful to the treatment of hepatitis C and other infectious diseases and bring a 'green revolution' in RNAI tools and therapeutics.
In a new study, researchers show that sun-exposed oyster mushrooms offer a readily available source of vitamin D that can help TB patients respond better to anti-TB drugs by improving immune response.
A faculty-led team of graduate and undergraduate researchers from Clemson University's Eukaryotic Pathogens Innovation Center has unveiled new findings that may help pave the way to an eventual cure for a parasitic infection that affects millions around the nation and world.
Proteasome inhibitors have significant promise as components of novel combination therapies to treat multidrug-resistant malaria, according to a study published June 6 in the open-access journal PLOS Pathogens by David Fidock, Caroline Ng, and Barbara Stokes of Columbia University Irving Medical Center, Matthew Bogyo of Stanford University School of Medicine, and colleagues.
The solution to the problem of increasing drug resistance among malaria-causing parasites could come from the North, according to a study published in Chemical Communications by researchers from Université Laval and the CHU de Québec Research Centre. The team successfully synthesized molecules discovered in a microscopic fungus from Nunavut and demonstrated their in vitro efficacy against the parasite responsible for malaria.