The Brain Metastasis Cell Lines Panel (BrMPanel) is the first to compile information on +60 cell lines related to brain metastasis research It was spearheaded by CNIO researcher Manuel Valiente, who coordinated its 19 constituent international laboratories and seeks to turn it into a 'white paper' for research in this area The goal is to streamline brain metastasis research for the development of therapies and to encourage new scientific teams to participate in studying this area
Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumor. A new study uncovers a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth.
Crop hybrid technologies have contributed to the significant yield improvement worldwide in the past decades. However, designing and maintaining a hybrid production line has always been complex and laborious. Now, researchers in China have developed a new system combining CRISPR-mediated genome editing with other approaches that could produce better seeds compared with conventional hybrid methods and shorten the production timeline by 5 to 10 years. The study appears July 8, 2020 in Molecular Plant.
If every cell has the same genetic blueprint, why does an eye cell look and act so differently than a brain cell or skin cell? In a new study published this week, researchers come one step closer to solving this mystery, showing RNA plays a critical role.
St. Jude Children's Research Hospital scientists have developed software to identify cancer-causing mutations lurking in vast regions of the human genome.
What causes African hybrid honey bees (AHB) or killer bees to be highly defensive and aggressive? York University researchers found it was the mixing of African and European genetics that led to hyper-aggression in this invasive strain of honey bees. Researchers in Brazil imported a honey bee subspecies from South African in the 1950s and bred them with European-derived honey bees, but bees escaped and mated with the local bees - an experiment gone wrong.
Response to the recent report of the deaths of two children receiving high doses of a gene therapy vector (AAV8) in a Phase I trial for X-linked myotubular myopathy (MTM). The news "is a tragic reminder of how difficult it is to predict outcomes in first-in-human studies
On May 5, 2020, news broke about a reportedly more contagious variant of SARS-CoV-2 based on a preprint posted to bioRxiv. On July 2, the journal Cell published a peer-reviewed version of the paper that offers additional experimental and clinical data about the D614G variant suggesting that it may be more infectious, but concludes that we still cannot be certain about whether the variant makes SARS-CoV-2 more transmissible or leads to more severe disease.
A research led by biomedical scientists from City University of Hong Kong (CityU) has developed a novel detection method, called CARPID, to identify binding proteins of specific RNAs in the living cells. It is expected the innovation can be applied in various cell researches, from identifying biomarkers of cancer diagnosis to detecting potential drug targets for treating viral diseases.
Researchers from the MDS Group of the Josep Carreras Leukaemia Research Institute and the Munich Leukemia Laboratory map the mutations that can ease and accelerate the diagnosis of Myelodysplastic/Myeloproliferative Neoplasms rare malignancies.