Researchers in Simon Fraser University's Brinkman Laboratory are collaborating with US researchers to test a new drug that can kill a wide range of superbugs -- including some bacteria now resistant to all common antibiotics.
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel computational algorithm to track the epidemiology of pediatric sepsis, allowing for the collection of more accurate data about outcomes and incidence of the condition over time, which is essential to the improvement of care.
Using physics to study different types of animal motion, such as burrowing worms or flying flocks, can reveal how animals behave in different settings. By using principles and technology from fields like fluid mechanics, scientists can track and measure animals in motion. At the 2020 American Physical Society March Meeting in Denver, researchers will present the various ways they quantify animal movement--and subsequently, better understand the animal world.
Cancer mutations can be caused by common gut bacteria. By exposing human mini-guts to a particular strain of Escherichia coli, scientist uncovered that these bacteria induce a unique mutational pattern in human DNA. This pattern was also found in colon cancer patients, implying that the bacteria induced these mutations. For the first time the researchers establish a direct link between microbes and mutations driving tumorigenesis. This might lead to new measures in colorectal cancer prevention.
A research team has described five new cases of a rare disease -- known as KAT6A syndrome -- of which there are only eighty dominant cases worldwide. This neurological and developmental disorder, caused by alterations in the lysine acetyltransferase 6A gene (KAT6A), involves intellectual disability, language impairment, low muscle tone, cardiovascular malformation and eye defects, among other affectations.
A group led by scientists from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have developed a new method, RADICL-seq, which allows scientists to better understand how RNA interacts with the genome through chromatin--the structure in which the genome is organized.
New live-cell drug discovery tool developed at the University of Toronto identifies two leukemia drugs and other small molecules as potential treatments for lung tumours that stopped responding to therapy.
Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center.
New research shows that both strands of microRNA cooperate to drive growth and aggressiveness across cancer types, suggesting that these molecules may be more central in deadly cancers than previously thought.
A massive analysis of the entire genomes of 2,658 people with 38 different types of cancer has identified mutations in 179 genes and gene regulators as 'drivers' -- variations in DNA sequences that lead to the development of cancer. The work is part of the Pan-Cancer Analysis of Whole Genomes project, one of the most comprehensive cancer genomics studies to date.