Medical University of South Carolina researchers investigated the effects of mutations altering the structure of an essential protein in an antibiotic-resistant strain of Neisseria gonorrhoeae. They report in the Journal of Biological Chemistry that the mutations do not simply block antibiotics from binding to the protein but lock the protein in a shape that reduces its ability to interact with drugs. The findings pave the way for developing new antimicrobials to treat gonorrhea.
Twin-to-twin transfusion syndrome (TTTS) occurs in around 10-15% of pregnancies with twins that share the same placenta. Typically, this syndrome appears before 24 weeks' gestation due to abnormal vascular communications located on the surface of the placenta. As a result, blood circulation is not balanced between the two twins, dramatically decreasing their chances of survival.
High-throughput platform identifies complex conditions with biomaterial compositions, and mechanical and chemical stimuli that help stem cells produce more robust cartilage.
Researchers have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.
The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes -- from growing disease-resistant crops to, more recently, a diagnostic test for the virus that causes COVID-19. Now a study involving fish that look nearly identical to the endangered Delta smelt finds that CRISPR can be a conservation and resource management tool, as well. The researchers think its ability to rapidly detect and differentiate among species could revolutionize environmental monitoring.
Engineers have demonstrated a method for ensuring that an increasingly popular method of genetic identification called "DNA fingerprinting" remains secure against inadvertent mistakes or malicious attacks in the field. The technique relies on introducing genetic "barcodes" to DNA samples as they are collected and securely sending information crucial to identifying these barcodes to technicians in the laboratory.
As the cell's protein factory, the ribosome is the only natural machine that manufactures its own parts. That is why understanding how the machine, itself, is made, could unlock the door to everything from understanding how life develops to designing new methods of drug production.
Scientists have discovered how liver cancer spreads, but they haven't yet learned how liver cancer cells are born. A team of Okayama University scientists has now established a model that demonstrates how, given the right body environment and without genetic mutation, normal stem cells can convert into cancer stem cells, which in turn proliferate and cause the cancer tumor to grow. Their model could help develop targeted drugs and therapies for liver cancer.
In the latest auto-commentary from SLAS Discovery, 'Controlling Phosphate Removal with Light: The Development of Optochemical Tools to Probe Protein Phosphatase Function,' researchers from the University of Pittsburgh Department of Chemistry (Pittsburgh, PA, USA) explain the design principles considered in developing an optically controlled protein phosphatase, opportunities and limitations of the methodology.
Customizable magnetic iron nanowires pinpoint and track the movements of target cells.