The June issue of SLAS Technology features two related research papers authored by Georges Muller, Ph.D., (SEED Biosciences, Switzerland) the SLAS2019 Ignite Award winner and a top ten 2020 SLAS Innovation Award finalist.
In this issue, Guest Editor Veli-Pekka Jaakola, Ph.D., (Confo Therapeutics, Belgium) highlights a series of articles focused on new screening tools and assays that find new chemical matter for medically relevant membrane protein targets
New findings reveal the importance of the Na/K-ATPase protein in stem cell differentiation and organogenesis, in a study led by scientists at Marshall University that involves the scaffolding function of the Na/K-ATPase.
A promising molecular pair has offered hope that could lead to the development of a new treatment to slow down Parkinson's disease, a study by Nanyang Technological University, Singapore (NTU Singapore) and Harvard University has found.
A mouse model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduces features observed in human patients, researchers report May 26 in the journal Cell Host & Microbe. Using CRISPR/Cas9 gene editing technology, the researchers generated mice that produce human angiotensin-converting enzyme II (hACE2)--the receptor that SARS-CoV-2 binds to and uses to enter human cells.
A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) pioneers the use of whole living cells (human lung adenocarcinoma) in dynamic combinatorial chemistry systems. This research, published in the journal Angewandte Chemie International Edition, proposes a new methodology to discover new bioactive molecules in a realistic biological medium. This methodology could help in the future to develop methods to differentiate healthy versus cancer cells, or to protect the extracellular matrix against pathogens.
Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. Reporting in Nature Cancer, the researchers showed for the first time in human cells and a mouse model that inhibiting the c-Rel molecule in myeloid cells -- as opposed to lymphoid cells that today's immunotherapies target -- blocked the production of immune suppressor cells and significantly shrank tumors.
Research led by the UPV/EHU-University of the Basque Country estimates that determining the mutational load of the mutation of the BRAF (BRAF-V600E) gene could predict whether the melanoma will progress to metastasis
A joint research team led by Sunney Xie, Director of Beijing Advanced Innovation Center for Genomics (ICG) at Peking University (PKU) has identified multiple highly potent neutralizing antibodies against the novel coronavirus SARS-CoV-2, the causative virus of the respiratory disease COVID-19.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin. The study, published in Diabetes, also revealed one protein--called PRDX4--that may be essential for proinsulin folding and insulin production. The research suggests that boosting PRDX4 levels may be a novel therapeutic approach to improving the health of people with diabetes.