A City of Hope scientist discovered a gene-editing technology that could efficiently and accurately correct the genetic defects that underlie certain diseases, positioning the new tool as the basis for the next generation of genetic therapies. This editing platform may be used to cure inherited and acquired diseases. The proof-of-concept study spotlights a promising new gene-editing platform that may eventually be used to treat diseases such as sickle cell disease, hemophilia and other genetic disorders.
A team of UCLA engineers and scientists discovered a new and potentially highly effective type of weed killer. This finding could lead to the first new class of commercial herbicides in more than 30 years, an important outcome as weeds continue to develop resistance to current herbicide regimens.
Currently, there are no treatments available to address internal bleeding in the field but early intervention is key or survival and better outcomes. UMBC researchers and collaborators investigated the role of nanoparticles they developed to stop internal bleeding on the damage inflicted by blast trauma.
Kyoto University researchers have developed a new approach to control the fabrication of soft, porous materials, overcoming a primary challenge in materials science.
New research has uncovered a protein enabling the replication of arenaviruses, pathogens now widespread in West Africa that are carried by rodents and can infect humans with lethal fevers. The research identified DDX3 as a key factor promoting arenavirus multiplication through its unexpected ability to promote viral RNA synthesis and dismantle normal human immune system defenses. The study may pave the way to new therapeutic treatments for arenaviruses and hemorrhagic fever.
Scientists at Kyoto University have used induced pluripotent stem cells to make platelets at numbers (> 100 billion) that can be used in the clinic. The ability comes from combining stem cell technology with bioreactors that incorporate turbulence. This artificial blood system is expected to replace blood donors for platelet transfusions.
When applied to cells, pulsed electric fields increase membrane permeability. Researchers have used this effect to force the diffusion of extracellular calcium into cells. Cell death occurs more easily in cancer cells since they are particularly sensitive to high amounts of calcium. Researchers from Kumamoto University in Japan have optimized pulsed electric field settings in an effort to attack cancer but leave healthy cells intact.
A team of bioengineers at UC San Diego has answered a question that has long puzzled neuroscientists, and may hold a key to better understanding the complexities of neurological disorders: why are neuron axons designed the way they are? The answer -- that they're designed to balance the speed that information flows into the neuron relative to the time it takes the neuron to process that information -- seems intuitive, but has never been quantified until now.
As allergy season intensifies, many people are cursing pollen -- the powdery substance released by plants for reproduction. However, pollen may serve a purpose beyond making new plants and triggering sneezes. In ACS Biomaterials Science & Engineering, researchers report a new method for cleaning out the insides of pollen grains so that the non-allergenic shells can be used to carry medicines or vaccines into the human body.
A wide range of fetal genetic abnormalities could soon be detected in early pregnancy thanks to a world-first study led by University of South Australia researchers using lab-on-a-chip, noninvasive technology.