A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. This is the first such synthetic enzyme to outperform its natural counterpart -- and it does so by three orders of magnitude.
Microelectrodes can be used for direct measurement of electrical signals in the brain or heart. These applications require soft materials, however. With existing methods, attaching electrodes to such materials poses significant challenges. A team at the Technical University of Munich (TUM) has now succeeded in printing electrodes directly onto several soft substrates.
A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.
The lungs can be a difficult organ to biopsy with a needle, so identifying lung cancer through a blood-based biopsy has lung cancer experts and patients optimistic. Knowing how and when to use a liquid biopsy is critically important and led global experts at the International Association for the Study of Lung Cancer (IASLC) to issue 'The IASLC Statement Paper: Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC),' available in the Journal of Thoracic Oncology.
Researchers have developed a new method for correcting the errors that creep into DNA barcodes -- labels used in a wide range of biological experiments -- yielding far more accurate results and paving the way for more ambitious medical research in the future.
Engineers have created an electronic 'skin' in an effort to restore a real sense of touch for amputees using prosthetics.
Carnegie Mellon University's Biomedical Engineering and Chemical Engineering Professors Bob Tilton and Todd Przybycien recently co-authored a paper with Ph.D. students Brittany Nordmark and Toni Bechtel, and alumnus John Riley, further refining a process that could soon help provide clean water to many in water-scarce regions. The process, created by Tilton's former student and co-author Stephanie Velegol, uses sand and plant materials readily available in many developing nations.
In a pilot study by a team of researchers at The University of Texas at Austin, crystalline particles of titanium dioxide -- the most common white pigment in everyday products ranging from paint to candies -- were found in pancreas specimens with Type 2 diabetes, suggesting that exposure to the white pigment is associated with the disease.
Bloodhounds are famous for their ability to track scents over great distances. Now researchers have developed a modern-day bloodhound -- a robot that can rapidly detect odors from sources on the ground, such as footprints. The robot, reported in ACS Sensors, could even read a message written on the ground using odors as a barcode.
A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes, report researchers at the University of Illinois. It enables researchers to study concurrent processes within cells and tissue, and could give cancer researchers a new tool for tracking tumor progression and physicians new technology for tissue pathology and diagnostics.