The pursuit of the usual suspect in Alzheimer's research may be distracting from a more direct culprit in the disease, according to a study that analyzed data from 51 published experiments. P-tau looked a good bit more culpable than amyloid-beta plaque.
New research published in The Journal of Physiology sheds light on the effects of high blood pressure by considering the way the body responds to a lack of oxygen.
A research study by the Universitat Autònoma de Barcelona (UAB) in collaboration with the University of La Laguna (ULL) demonstrates in mice the biological relevance of sex in the effects of accelerated ageing caused by a chronic treatment of D-galactose.
Researchers at UNIGE found that socio-economically disadvantaged individuals in childhood are a greater risk of low muscle strength at an older age. Moreover, this risk is not offset by an improvement in their socio-economic status as adults. This means that inequalities in childhood are biologically embodied to literally 'get into the skin'. Why? They suggest that a physiological deregulation caused by stress in childhood might change the body's ability to maintain good health along time.
How does the father's age at conception affect his children? DZNE researchers have studied this question in mice. Their findings show that the offspring of elderly mouse-fathers had a shorter lifespan than those of young fathers and featured an exacerbation of a number of histopathological and molecular aging traits. Moreover, sperm of old males as well as the tissue from old father offspring featured shared epigenetic changes and altered activation states of longevity-related signaling pathways.
Hydroxychloroquine is no more effective than placebo for relieving moderate to severe hand pain and radiographic osteoarthritis. The findings of a randomized trial are published in Annals of Internal Medicine.
Dr. Emery Brown, an MIT neuroscientist and MGH anesthesiologist, has combined scientific and statistical methods to put the brain at the center of anesthesiology practice. By deciphering and monitoring EEG readings in real time he can more optimally dose patients under general anesthesia. He's presenting at the 2018 AAAS Annual Meeting, Friday Feb. 16.
A new study from Indiana University Center for Aging Research and the Regenstrief Institute compares quality of hospice services provided for patients living at home, in assisted living facility and in nursing homes as perceived by family members. Findings, which reveal subtle but significant differences in perceived quality have potential to help influence priorities for improvement of quality, patient choice of hospice service provider and reimbursement for these services.
A study from scientists at The Scripps Research Institute (TSRI) explains why the risk of osteoarthritis increases as we age and offers a potential avenue for developing new therapies to maintain healthy joints.
Nerve fibers are surrounded by a myelin sheath. Scientists at the Technical University of Munich (TUM) have now made the first-ever "live" observations of how this protective layer is formed. The team discovered that the characteristic patterns of the myelin layer are determined at an early stage. However, these patterns can be adjusted as needed in a process apparently controlled by the nerve cells themselves.