Rice University scientists are analyzing the role of ferredoxin proteins produced when viral phages alter electron transfer in ocean-dwelling, photosynthetic bacteria that produce oxygen and store carbon.
High-throughput platform identifies complex conditions with biomaterial compositions, and mechanical and chemical stimuli that help stem cells produce more robust cartilage.
Work by a Rice neurobiologist shows that increased blood flow to the brain is not an accurate indicator of neuronal recovery after a microscopic stroke.
MIPT biophysicists explained ways to visualize membrane receptors in their different states. Detailed information on the structure and dynamics of these proteins will enable developing effective and safe drugs to treat many sorts of conditions.
The paper describes how to minimize or eliminate side effects in drugs that target G protein-coupled receptors. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of prescription drugs, including antihistamines, beta blockers and opioids. 'Armed with our results, researchers can begin to imagine new and better ways to design drugs that retain their effectiveness while posing fewer dangers.'
Generative biology meets generative chemistry: bidirectional conditional autoencoder to generate novel molecular structures for the desired transcriptional response.
Russian researchers have developed a novel method for diagnosing and monitoring autoimmune disorders. Within a mere 25 minutes, their new biosensor not only measures the concentration of autoantibodies in human blood serum with extremely high sensitivity, but also -- for the first time -- quantifies their activity. The combination of these parameters permits the elaboration of new diagnostic criteria for autoimmune diseases, as well as new approaches to their treatment.
The Chemical Checker provides processed, harmonized and ready-to-use bioactivity information on more than 1M small molecules. The tool, developed by the Structural Bioinformatics and Network Biology lab at IRB Barcelona, has been published in Nature Biotechnology.
Scientists at Osaka University develop a liquid-phase method for 3D-printing nanocellulose fibers aligned in multiple directions. This work may help with the development of new smartphone screens or electronics printed on paper.
Airborne transmission of viruses, like the virus causing COVID-19, is not well understood, but a good baseline for study is a deeper understanding of how particles travel through the air when people cough. In Physics of Fluids, researchers discuss a simulation they created that examines saliva droplets moving through the air in front of a coughing person. The work shows that with a slight breeze of 4 kph, saliva travels 18 feet in 5 seconds.