A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its suitability and reliability for application to early drug discovery campaigns.
Research shows for the first time that when adults are engaged in joint play together with their infant, the parents' brains show bursts of high-frequency activity, which are linked to their baby's attention patterns and not their own. The study publishes December 13 in the open-access journal PLOS Biology and was conducted by Dr Sam Wass of the University of East London in collaboration with Dr Victoria Leong (Cambridge University and Nanyang Technological University, Singapore) and colleagues.
Louis Populin and collaborators at the University of Wisconsin-Madison collaborators published a study this week in the Journal of Neuroscience describing increased connections between key parts of the brains of monkeys who have taken methylphenidate (Ritalin).
The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized and characterized using advanced spectroscopic techniques such as NMR, HR-MS and IR.
Permafrost thaw slumps in the western Canadian Arctic are releasing record amounts of mercury into waterways, according to new research by University of Alberta ecologists.
Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs that cause specific proteins to associate more or less with their 'coworkers.' Now, researchers reporting in ACS' journal Analytical Chemistry have developed a method to visualize whether drugs are regulating protein-protein interactions inside cells.
It costs the global economy an estimated US $2 trillion annually and has been dubbed a modern day health epidemic, but new research from the University of South Australia has unearthed a possible cure for obesity -- and it is as plain as dirt!
Washington State University researchers have reverse engineered the way a pine tree produces a resin, which could serve as an environmentally friendly alternative to a range of fossil-fuel based products worth billions of dollars.
Researchers at Kanazawa University report in The Journal of Organic Chemistry that carboxylic acids, functional groups contained in biomolecules, drugs, and materials can be readily modified by light-induced organic reactions using an aminocyclopropenone. This discovery opens up new pathways for carboxylic acid modification with potential applications including determination of drug target proteins, elucidation of protein function, and synthesis of functionalized polymer materials.
They approach with the telltale sign -- a high-pitched whine. It's a warning that you are a mosquito's next meal. But that mosquito might carry a virus, and now the virus is in you. Now, with the help of state-of-the-art technology, researchers at the University of Missouri can see how a virus moves within a mosquito's body, which could lead to the prevention of mosquitoes transmitting diseases.