A team of researchers has identified numerous mutations that allow the malaria-causing parasite Plasmodium falciparum to become resistant to treatment. Knowing the identity of genes that impart multidrug resistance is important for the design of new drugs, and for understanding how existing therapeutics can lose their efficacy in clinical settings.
A protein pivotal to how the brain acquires knowledge originated from a chance evolutionary event that occurred hundreds of millions of years ago. The protein, called Arc, is involved in storing long-term memories and learning. But new research shows that Arc looks and acts like a protein from viruses, report scientists at University of Utah Health.
As carbon dioxide (CO2) levels in the atmosphere rise, more CO2 gets absorbed into seawater. As a result, the world's oceans have grown more acidic over time, causing a wide range of well-documented problems for marine animals and ecosystems. Now, researchers reporting in Current Biology on Jan. 11 present some of the first evidence that similar things are happening in freshwaters too.
From the time of Hippocrates, physicians have suspected a link between epilepsy and depression. Now, for the first time, scientists at Rutgers University-New Brunswick and Columbia University have found evidence that seizures and mood disorders such as depression may share the same genetic cause in some people with epilepsy, which may lead to better screening and treatment to improve patients' quality of life.
Despite herculean efforts, cancer remains a formidable disease, with each malignant subtype responding differently to therapeutics. One hurdle specific to treating solid tumors is a protective layer called an extracellular matrix that can prevent chemotherapeutic agents from penetrating the tumor's core. Scientists now report results in ACS' Chemistry of Materials showing that, by cloaking anti-cancer drugs in a specially designed particle, they could target and destroy tumor cells deep inside a malignant mass in vitro.
A new design of algae-powered fuel cells that is five times more efficient than existing plant and algal models, as well as being potentially more cost-effective to produce and practical to use, has been developed by researchers at the University of Cambridge.
ETH chemists have synthesized several variants of THC, the active ingredient in cannabis. Its structure can be altered with light, and the researchers have used this to create a new tool that can be used to more effectively study the body's own cannabinoid system.
Salk researchers have discovered how to curb the growth of cancer cells by blocking the cells' access to certain nutrients.
To make a solid crystal, molecules are generally so tightly packed together there's no room for any movement. It means that solid crystals -- despite their strength and durability -- have generally been ignored as having any possible function as molecular machines. UCLA researchers have formed a crystal out of molecules that look like gyroscopes. The crystal is externally solid but contains moving parts.
From cars and bicycles to airplanes and space shuttles, manufacturers around the world are trying to make these vehicles lighter, which helps lower fuel use and lessen the environmental footprint. But with the industry relying on petroleum products to make carbon fiber today, could we instead use renewable sources?