Median survival after lung transplant is less than six years. To see what might help lung transplant recipients live longer, University of Maryland School of Medicine researchers analyzed US lung transplant data, focused on immunosuppression regimes, and found a drug combination that appears to significantly extend patient survival.
French organ transplant centers are far more likely to accept 'lower-rated' kidneys, like those from older organ donors, than centers in the United States, according to an analysis published today in JAMA Internal Medicine. French transplant centers would have transplanted more than 60% -- about 17,500 kidneys -- of the nearly 28,000 deceased-donor kidneys discarded in the United States between 2004 and 2014, according to the research team from Penn Medicine and the Paris Transplant Group.
Researchers from EPFL and the University Medical Center Utrecht in the Netherlands have developed an extremely fast optical method for sculpting complex shapes in stem-cell-laden hydrogels and then vascularizing the resulting tissue. Their groundbreaking technique stands to change the field of tissue engineering.
A serious case of the flu can cause lasting damage to the lungs. In a study in mice, researchers from the University of Pennsylvania and colleagues found that transplanting cells from the lungs of healthy animals enhanced healing in others that had had a severe respiratory infection.
Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants. But pluripotency is still a black box for science, controlled by unknown genetic and epigenetic signals. CNIO researchers now uncovers one of those epigenetic signals, after a detective quest that started almost a decade ago.
'The role of mitochondria has been largely ignored in the field of regenerative medicine, but earlier efforts in our lab suggested that they may affect the outcome of stem cell transplants,' said Tobias Deuse, M.D., the Julien I.E. Hoffman Chair in Cardiac Surgery at UCSF and lead author of the new study, published Aug. 19 in Nature Biotechnology.
Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.
Research from the University of Cincinnati finds that among women who are kidney transplant recipients, Hispanic women have a higher likelihood of pregnancy than white women.
As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team comprising scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing MI heart, as an alternative to heart transplant.
A new study from the University of Eastern Finland shows that the health-related quality of life of most people who have or have a higher risk of knee osteoarthritis remained unchanged over an eight-year trajectory. Worsening of quality of life was associated with several risk factors, such as obesity and smoking, and it also reflected the patient's need for treatment.