A research team led by Dr. DU Xuemin at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences created a new shape-morphing scaffold, enabling programmed deformation from a 2D planar cell-laden structure to a well-defined 3D tubular shape, which facilitated the facile 3D endothelialization of small-diameter vascular grafts.
A rare opportunity to analyze both blood and tissue samples from human transplant recipients may lead to improved ways of identifying transplant recipients at risk of rejection and treating autoimmune disease.
How do complex biological structures -- an eye, a hand, a brain -- emerge from a single fertilized egg? This is the fundamental question of developmental biology, and a mystery still being grappled with by scientists who hope to one day apply the same principles to heal damaged tissues or regrow ailing organs.
Researchers at Washington University School of Medicine in St. Louis and Northwestern University have uncovered cells that flow into and harm the lung soon after transplant. The resulting dysfunction is the leading cause of early death after lung transplantation and contributes to organ rejection that can lead to death months or years later. The discovery, in mice, may lead to drug therapies that target the destructive cells.
An early study suggests it may be feasible to use human aortic grafts preserved by freezing to rebuild windpipe and airway sections removed because of disease.
Rutgers University-New Brunswick engineers have created a 3D-printed smart gel that walks underwater and grabs objects and moves them. The watery creation could lead to soft robots that mimic sea animals like the octopus, which can walk underwater and bump into things without damaging them. It may also lead to artificial heart, stomach and other muscles, along with devices for diagnosing diseases, detecting and delivering drugs and performing underwater inspections.
By expanding the donation pool to include currently deemed 'unfit' organs, researchers say the gap could be closed or narrowed, resulting in more lives saved.
The researchers examined 17 years of transplantation records and found no significant change in the recipients' chance of survival when the organ donation came from victims of drug intoxication. The study publishes online on May 17 in the New England Journal of Medicine.
Lung transplant patients who showed evidence of alcohol use before their transplants spent more time in the hospital and on the ventilator, according to a Loyola University Chicago study. Researchers said abstaining from alcohol before transplant could improve outcomes.
A new study in Scientific Reports paves the way for translational research examining cardiovascular disease risk factors associated with short-term BPA exposure in infancy. By examining neonatal rat heart cells, Children's National researchers find the immature heart may respond to BPA with a slowed heart rate, irregular heart rhythm and calcium instabilities. The significance of this research is that plastics revolutionized the way doctors treat young patients, especially patients with compromised immune or cardiac function.