In a paper in Cell Host & Microbe, scientists provide a statistical model predicting which bacterial strains will engraft after a fecal transplant. It is the first predictive strategy for developing a synthetic probiotic. The researchers also found that recipients acquired new bacteria that were previously undetected in both the donor and the recipient, suggesting that the post-fecal transplant microbiome is a mixture of bacterial strains from the donor, recipient, and the environment.
Future Science Group (FSG) today announced the publication of an article in Future Science OA demonstrating the first use of multispectral imaging in gynecology, in a uterine transplant setting.
In a new Johns Hopkins study of patient and graft survival trends for pediatric liver transplant recipients between 2002 and 2015, researchers found that outcomes for alternatives to whole liver transplantation (WLT), such as splitting a liver for two recipients or using a part of a liver from a living donor, have improved significantly.
A research team from Tongji University in China have made a breakthrough in human lung regeneration technology. For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot clinical trial. The study can be found in the open-access journal Protein & Cell which is published by Springer Nature.
Before medical science can bioengineer human organs in a lab for therapeutic use, two remaining hurdles are ensuring genetic stability -- so the organs are free from the risk of tumor growth -- and producing organ tissues of sufficient volume and size for viable transplant into people. Scientists report in Stem Cell Reports achieving both goals with a new production method for bioengineered human gut and liver tissues.
Monitoring and treating de novo donor-specific antibodies before they could cause graft damage helped to decrease dnDSA in a majority of pediatric kidney transplant recipients at Children National Health System and prevented graft failure in the first few years.
The first study of its kind to gather transplant data from across the UK and Ireland found patients have the best chance of long term survival where the donor and recipient have genetic matches in a section of DNA known as the HLA locus. This finding could help to personalise treatment and reduce costs to the NHS as patients need less treatment or spend less time in hospital.
The risks of penile reconstruction surgery (phalloplasty) appear higher in female-to-male transgender (transmale) patients undergoing gender confirmation surgery, compared to native male (cismale) patients undergoing phalloplasty for other reasons, reports a study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Researchers have discovered a new technique that overcomes one of the major challenges of stem cell therapy. A drug, co-created by UBC researchers, might overcome one of the major challenges of stem cell therapy -- their tendency to differentiate, becoming specific tissue cells too early and too quickly.
Parents' major concerns about child organ donation often included misunderstandings about medical care, potential suffering and cost.