Researchers at Osaka University applied molecular evolutionary analysis to quantify the severity of negative selection pressures on genes encoding the pneumococcal choline-binding proteins (CBPs). They found particularly strong selective constraints on the gene cbpJ, suggesting its importance for bacterial infection. Further analyses revealed its role in bacterial evasion of host neutrophils, suggesting CbpJ's value as a target for drugs against streptococci.
- Communications Biology
- Japan Society for the Promotion of Science, SECOM Science and Technology Foundation, Takeda Science Foundation, GSK Japan Research Grant, Asahi Glass Foundation, Kobayashi International Scholarship Foundation