Researchers from the National University of Singapore have created a new collection of atomically thin two-dimensional materials. Using novel synthesis conditions for transition metal dichalcogenides, more than 10 new materials have been made by the team, with many more still to be discovered.
In this research, the researchers offer an overview on state-of-the-art approaches for the high-confidence identification and accurate quantification of protein arginine methylation by high-resolution mass spectrometry methods, which comprise the development of both biochemical and bioinformatics methods.
Medical University of South Carolina researchers investigated the effects of mutations altering the structure of an essential protein in an antibiotic-resistant strain of Neisseria gonorrhoeae. They report in the Journal of Biological Chemistry that the mutations do not simply block antibiotics from binding to the protein but lock the protein in a shape that reduces its ability to interact with drugs. The findings pave the way for developing new antimicrobials to treat gonorrhea.
The carbon-hydrogen bond -- 2/3 of all bonds in hydrocarbons -- has defied chemists' attempts to open it up and add new chemical groups. A UC Berkeley team has now cracked the strongest of C-H bonds, those on a molecule's terminal carbon. The reaction catalyst is an iridium atom to break the bond and a methyl group to add a boron compound. Boron is easily exchanged for other groups, allowing additions to hydrocarbons and natural products.
Researchers from the Muñiz group have published a paper in Angewandte Chemie -- International Edition presenting a new metal-free methodology for the photo-catalysed nucleophilic fluorination of aliphatic hydrocarbon bonds. Daniel Bafaluy, first author of the paper shares the story behind it:
Results from a study conducted by a research team led by C. Patrick Reynolds, M.D., Ph.D., director of the Texas Tech University Health Sciences Center School of Medicine Cancer Center, may prove to be a landmark in pediatric oncology. The research, "Telomere maintenance mechanisms define clinical outcome in high-risk neuroblastoma," was published April 14 by Cancer Research and may lead to revisions of the risk stratification process for neuroblastoma, one of the deadliest childhood cancers.
New research from the University of East Anglia (UEA) recommends changes to the system which sees drug companies strike deals with competitors to stop them producing cheaper generic alternatives.
For decades, scientists have explored the use of liposomes -- hollow spheres made of lipid bilayers -- to deliver chemotherapy drugs to tumor cells. But drugs can sometimes leak out of liposomes before they reach their destination, reducing the dose received by the tumor and causing side effects in healthy tissues. Now, researchers report in ACS' Nano Letters a way to stabilize liposomes by embedding a stiff nanobowl in their inner cavity.
Generative biology meets generative chemistry: bidirectional conditional autoencoder to generate novel molecular structures for the desired transcriptional response.
Scientists from Hong Kong Baptist University (HKBU) have developed a novel technique that can produce pure therapeutic drugs without the associated side effects.