The information presented in this study is primarily positioned to benefit scientists and experts in Cellular Physiology and Histochemistry where new tools to discover therapeutic targets for muscle atrophy are needed. The study outlines the development of a new fluorescent reporter mouse line to detect changes in mitophagy activity. These findings could revolutionize treatment strategies and possibly facilitate interventions to reverse disuse-induced muscle atrophy.
State-of-the-art video microscopy has enabled Australian researchers to see the molecular details of how malaria parasites invade red blood cells - a key step in the disease.
USC researchers have created what could be a key building block for assembling a synthetic kidney. In a new study, Zhongwei Li and his colleagues describe how they generate rudimentary kidney structures, known as organoids, that resemble the collecting duct system that helps maintain the body's fluid and pH balance by concentrating and transporting urine. The organoids provide a way to study kidney disease that could lead to new treatments and regenerative approaches for patients.
There is increasing scrutiny around how science is communicated to the public, but what is the relationship between how scientists report their findings and how media reports it to the public? A study published in PLOS Biology by Marcia Triunfol and Fabio Gouveia suggests that when authors of scientific papers omit the basic fact that a study was conducted in mice (and not in humans) from the article title, journalists reporting on the paper tend to do the same.
A new therapy prompts immune defense cells to swallow misshapen proteins, amyloid beta plaques and tau tangles, whose buildup is known to kill nearby brain cells as part of Alzheimer's disease, a new study shows.
Discussions of a broken value system are ubiquitous in science, especially after the COVID-19 pandemic served to expose inequality globally. However, according to the authors of an article publishing 15th June 2021 in the open access journal PLOS Biology, science itself is not "broken," but it was built on deeply-entrenched, systemic sexist and racist values, which perpetuate biases through the continued focus on citation rates and impact factors.
Expose crayfish to antidepressants, and they become more outgoing -- but that might not be such a positive thing for these freshwater crustaceans, according to a new study.
A previously unreported anatomical structure named the 'cantil' has been described in the popular plant model, Arabidopsis thaliana. Scientists from The Pennsylvania State University, USA, reveal that the cantil forms between the stem and flower-bearing stalk when flowering is delayed. Published in the journal Development, this study highlights that there are still discoveries to be made, even in some of the most meticulously studied species, and provides new clues for understanding conditional growth in plants.
Makeup wearers may be absorbing and ingesting potentially toxic per- and polyfluoroalkyl substances (PFAS), according to a new study. The researchers found high fluorine levels--indicating probable presence of PFAS--in about half of makeup tested. Some products underwent further analysis and were all confirmed to contain at least four PFAS of concern. Most products had no PFAS listed on the label.
Study published in PLoS Biology shows that Alzheimer disease experimental papers that omit mice from their titles are linked to more science news stories and gain greater visibility. The finding points to yet another type of spin in the reporting of biomedical research.