Rice University scientists develop cHAT to simplify the reduction of alkenes to more useful intermediate molecules for drugs and other useful chemical compounds.
In a recent study, a research group led by Christian Gruber at MedUni Vienna's Institute of Pharmacology isolated a peptide (small protein molecule) from beetroot. The peptide is able to inhibit a particular enzyme that is responsible for the breakdown of messenger molecules in the body. Due to its particularly stable molecular structure and pharmacological properties, the beetroot peptide may be a good candidate for development of a drug to treat certain inflammatory diseases, such as e.g. neurodegenerative and autoimmune diseases.
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have designed a light-sensitive inhibitor that can control cell division and cell death - and provides a promising approach for studies of essential cellular processes and the development of novel tumor therapies.
Analysis identified 525 genes encoding proteins that act on the nervous system, cardiovascular system and cell walls. One of the molecules proved effective against cancer cells in preliminary test results.
Anti-NMDAR encephalitis is an autoimmune brain illness that is often mistaken by a psychiatric disorder since it causes psychoses and other behaviour alterations. Despite having these similarities, the illness does not respond to common antipsychotic treatments.
They look like microscopic bottle brushes: Polymers with a backbone and tufts of side arms. This molecular design gives them unusual abilities: For example, they can bind active agents and release them again when the temperature changes. With the help of neutrons, a research team from the Technical University of Munich (TUM) has now succeeded to unveil the changes in the internal structure in course of the process.
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly used in the treatment of elevated cholesterol, but the new results may help design drugs for a number of conditions.
One of the proteins on the virus - located on the characteristic COVID spike - has a component called the receptor-binding domain, or RBD, which is its "Achilles heel." That is, he said, antibodies against this part of the virus have the potential to the neutralize the virus.
Researchers at the University of Basel have developed a precisely controllable system for mimicking biochemical reaction cascades in cells. Using microfluidic technology, they produce miniature polymeric reaction containers equipped with the desired properties. This 'cell on a chip' is useful not only for studying processes in cells, but also for the development of new synthetic pathways for chemical applications or for biological active substances in medicine.
A huge global research effort is taking place to bring a fast-tracked COVID-19 vaccine to the market but there is concern that certain countries may prioritise their own population's access to any vaccines developed. New RAND Europe research shows that if some countries are unable to obtain vaccines owing to vaccine nationalism it could cost the global economy up to $1.2 trillion per year in GDP terms.