Mail-order prescriptions shipped in standard bubble-padded envelopes during winter and summer months are likely to spend a substantial portion of time outside the recommended safe temperature range for most medications, according to research presented at the American Society for Health-System Pharmacists (ASHP) Midyear Clinical Meeting and Exhibition.
The mental symptoms of premenstrual dysphoric disorder improve following treatment with a progesterone receptor modulator, as demonstrated by SciLifeLab researcher Erika Comasco and Professor Inger Sundström-Poromaa, Uppsala University. The mechanism of action of the study drug provides insights into the potential molecular mechanisms underlying this psychiatric disorder and its treatment.
An interim analysis from the Swedish Drug-Elution Trial in Peripheral Arterial Disease (SWEDEPAD) has now been presented. It shows that, for patients with lower limb occlusive arterial disease, paclitaxel-coated balloons and stents do not bring about the rise in mortality previously reported. The study, led by the University of Gothenburg and published in The New England Journal of Medicine (NEJM), is expected to resonate internationally.
An enzyme in the colon lining releases hydrogen peroxide - a known disinfecting compound- to protect the body from gut microbial communities. Findings from the UC Davis Health study points to the importance of considering a different approach to treating gut inflammation and bacterial imbalance in the colon.
A study conducted on mice published in the journalGeroscience has identified the action mechanism of a promising compound against Alzheimer's disease, developed by the team of Medical Chemistry and Pharmacology at the University of Barcelona. The new drug belongs to a family of molecules that, when bound to imidazole I2 receptors, these cause a reduction in neuroinflammation and an improvement in cognition and other markers of the progression of this disease, the most prevalent among dementias.
Updated national guidelines for treating infections caused by the deadly superbug Clostridioides difficile (C. diff) have been examined and approved by a nationally renowned C. diff researcher at University of Houston and his team of students.
DNP, a weight loss agent withdrawn from the market in the late 1930s due to acute toxicity, has become increasingly popular in recent years through online illegal sales. A new study using a lifelong DNP treatment in an avian model found that while no obvious toxic effects were detected on the short to medium-term, DNP reduces lifespan by 20% on the long run.
A recent analysis of published studies provides a comprehensive overview of the terms and definitions used to characterize medicine misuse. The findings are published in the British Journal of Clinical Pharmacology.
A non-hallucinogenic version of the psychedelic drug ibogaine, with potential for treating addiction, depression and other psychiatric disorders, has been developed by researchers at UC Davis.
Protein therapies are often more potent and selective toward their biochemical targets than other types of drugs, particularly small molecules. However, proteins are also more likely to be quickly degraded by enzymes or cleared from blood by the kidneys, which has limited their clinical use. Now, researchers reporting in ACS Central Science have engineered red blood cell (RBC) carriers that release therapeutic proteins when stimulated by light, with the help of a honey bee peptide.