Atom-scale models of proteins that incorporate ligands, like drug molecules, shows a strong correlation between minimally frustrated binding sites and drug specificity. Such models could lead to better-designed drugs with fewer side effects.
Excessive calcium contributes to harmful inflammation in ischemic stroke, and targeting it may provide doctors with a new way to improve patient outcomes.
A new technique to make cheaper more efficient biological enzyme hybrids could have valuable applications in future water recycling, targeted drug manufacturing and other industries, Flinders University green chemistry researchers say in a new publication. The model enzyme system, which immobilises a catalyst enzyme hybrid for continuous flow use in the high-speed vortex fluidic device, showed a 16-fold increase in its efficiency, the researchers say in American Chemical Society journal, ASC Applied Materials & Interfaces.
When it comes to curbing the spread of COVID-19, test frequency and test turnaround-time are far more important than test sensitivity, according to a new study published in the journal Science Advances. The authors say frequent, rapid tests make "personalized stay-at-home orders" possible.
The cell membrane is impermeable to viruses: to get inside a cell, they have to exploit the biochemical properties of the membranes. The thiol-mediated uptake is one of the entry mechanisms. A research group from the University of Geneva has identified inhibitors of thhis cellular entry that block viruses expressing the SARS-CoV-2 proteins. The study paves the way for research into new antivirals.
For more than a decade, TTUHSC's Hiranmoy Das, Ph.D., has been investigating how KLF2 influences the development of bone and musculoskeletal diseases. Most recently, Das attempted to determine if inducing KLF2 levels in dental pulp derived stem cells will promote osteoblast and the building of new bone. His study, "KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism," was published in the September issue of Redox Biology.
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology, that addresses the gap in the discovery of new antibiotics.
Stopping the replication of SARS-CoV-2 is likely possible thanks to a compound called EBSELEN: a group of researchers from the Politecnico di Milano has communicated aspects relevant to the blocking of replication mechanism in the New Journal of Chemistry.
Researchers have identified a new druggable target for heart failure in neonates and infants. Approximately 60 percent of children born with congenital heart abnormalities will develop overt heart failure within the first year of life. The progression of heart failure in these infants is often rapid, with a high frequency of fatalities. Stimulation of this target significantly increased the cardiac contractility of newborns and infants in mice with few side effects.
Scientists at Osaka University discovered a new method for producing sodium titanate mats nanostructured in a seaweed-like morphology for filtering heavy metal ions and radioactive materials from water. This work may lead to advances in treating contaminated wastewater.