Researchers from Kanazawa University have found that propionic acid-class nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, form "conjugates" with coenzyme A (CoA) by one of the acyl-CoA synthetases, ACSL1, in liver. These conjugates have the covalent binding ability to cellular proteins that may lead to liver injury, a rare severe side effect of NSAID treatment. This knowledge could help pharmaceutical companies to generate pain control options with fewer risks of severe side effects.
A new study has found that there is no protection against colorectal cancer if people begin taking aspirin regularly after age 70. However, there appears to be such protection if aspirin is started before age 70 and continued.
This randomized clinical trial compares the effects of three doses of bamlanivimab monotherapy (700 vs 2,800 vs 7,000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate COVID-19.
This study estimated the frequency of reported forgone medical care because of the COVID-19 pandemic from March to mid-July 2020, including missed doses of prescription medications, forgone preventive and other general medical care, mental health care and elective surgeries, as well as reasons for forgoing care.
Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the British Journal of Clinical Pharmacology.
Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers.
In a new study, Luis H. Cisneros and his colleagues describe the effects of antibiotics on membrane vesicles, demonstrating that such drugs actively modify the properties of vesicle transport. Under the influence of antibiotics, MVs were produced and released by bacteria in greater abundance and traveled faster and further from their origin. The work sheds new light on these important information-carrying entities, implicated in many cellular communication processes, including antibiotic resistance.
Polymer and radionuclide chemists report major advance in microcapsule drug delivery systems. Their microcapsules -- labeled with radioactive zirconium-89 -- are the first example of hollow polymer capsules capable of long-term, multiday positron emission tomography imaging in vivo. In previous work, the researchers showed that the hollow capsules could be filled with a potent dose of the cancer drug doxorubicin, which could then be released by therapeutic ultrasound that ruptures the microcapsules.
In an article published in Nature Communications, Brazilian researchers show for the first time that in severe cases of scorpion envenomation it is the neuroimmune reaction triggered by the venom that leads to death.
This is a non-coding section of the RNA, which means that it is not translated into a protein, but it is likely key to the virus's replication.