A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed for the first time in the world that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).
As new lead protection rules from the Environmental Protection Agency move toward finalization, research shows that tens of thousands of children are at increased risk under the current set of inconsistent standards.
A team of researchers have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.
This observational study looked at whether race and socioeconomic factors were associated with children enrolled in national clinical trials receiving high-cost proton radiotherapy for treatment of cancer.
Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that a set of genes with decreased expression in individuals with Down syndrome may lead to clinical abnormalities in this population, such as poor muscle development and heart valve problems. Impairment in these same genes may also protect people with Down syndrome from developing solid tumors. Their findings were published in Scientific Reports.
Children's pester power may contribute to improvements in their family's food environments. A new study in the Journal of Nutrition Education and Behavior, published by Elsevier, highlights the potential for children to influence food consumption and habits at home.
Eosinophils residing in the airways of mice respond to influenza A virus (IAV) infection through alterations in surface expression of various markers necessary for migration and cellular immunity responses, according to research published in the Journal of Leukocyte Biology by researchers from Le Bonheur Children's Hospital and the University of Tennessee Health Science Center.
New research shows that children's own temperament could be driving the amount of TV they watch. The research shows how the brain responses of 10-month-old babies watching a clip from Disney's Fantasia on repeat could predict whether they would enjoy watching fast-paced TV shows six months later. The findings are important for the ongoing debate around early TV exposure.
As school districts look ahead to a very different school year, pediatric infectious disease experts from across the United States convened to outline back-to-school safety guidelines for solid organ transplant (SOT) recipients. The group, led by Kevin J. Downes, MD, attending physician in the Division of Pediatric Infectious Diseases at Children's Hospital of Philadelphia (CHOP), published their recommendations today in the Journal of the Pediatric Infectious Diseases Society.
Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of--and a treatment for--a previously unknown severe auto inflam-matory syndrome affecting an 18-year-old girl since infancy.