Nonalcoholic fatty liver disease (NAFLD) severely impairs the quality of life in patients and often leads to various liver complications. Recently, scientists at Gwangju Institute of Science and Technology designed a novel compound that can potentially treat NAFLD by targeting peripheral serotonin, which regulates lipid metabolism in the liver. They achieved this by structurally modifying an existing neurological drug such that it targets peripheral serotonin by minimizing brain penetration.
A new study shows that people with a rare genetic disease that causes bleeding in the brain have gut microbiomes distinct from those without the disease. Moreover, it is the molecules produced by this bacterial imbalance that cause lesions to form in the brains of these patients.
The earliest brain changes due to Huntington's disease can be detected 24 years before clinical symptoms show, according to a new UCL-led study published in The Lancet Neurology.
Researchers have found a way to design an antibody that can identify the toxic particles that destroy healthy brain cells -- a potential advance in the fight against Alzheimer's disease.
A new study due to be presented at the European Academy of Neurology (EAN) Virtual Congress shows the burden of potentially avoidable epilepsy-related deaths in young adults remains large, with those aged between 16 and 24 having a six-fold increased risk of epilepsy-related death.
Scientists have pinpointed the electrophysiological mechanism behind upper motor neuron disease, unlocking the door to potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, such as Hereditary Spastic Paraplegia and Primary Lateral Sclerosis.
The research, published in Current Biology, is one of the first comprehensive characterizations of poorly formed memories and may offer a framework to explore different therapeutic approaches to fear, memory and anxiety disorders. It may also have implications for accuracy of some witness testimony.
In a recent breakthrough, a team of HKUST scientists developed an adaptive optics two-photon excitation fluorescence microscopy using direct wavefront sensing for high-resolution in vivo fluorescence imaging of mouse retina, which allow in vivo fundus imaging at an unprecedented resolution after full AO correction.
Scientists have developed a head-mounted miniature microscope, the so-called fiberscope, that is capable of imaging all cortical layers of a freely moving rat
Center for BrainHealth published findings underscoring differences between men and women's craving or desire to consume cannabis when exposed to a specific situation. Examining differences in neural and subjective craving responses, and measuring the relative contributions of each as it relates to heavy cannabis use, they found that neural activity primarily underlies response to cannabis cues with no differences between male and female users. This is followed by subjective craving, where there are sex-related differences.