Dangerous antibiotic-resistant bacteria could soon be targeted with a drug initially developed to treat Alzheimer's disease. University of Queensland-led research investigated the antibacterial properties of metal transport drug, PBT2.
Scientists who recently identified the molecular start of Alzheimer's disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time -- a form of personalized medicine for neurodegenerative diseases.
An international group of collaborating scientists that includes HSE Professor Vasily Vlasov has analyzed data from 195 countries on the spread of Alzheimer's disease and other dementia between 1990 and 2016. The results have been published in the journal The Lancet Neurology.
New research reveals the costs and trade-offs of reforming long-term care for older people in England. The report comes ahead of a long-awaited government Green Paper on Social Care. It shows that a £36,000 lifetime cap on care costs for older people (similar to that recommended by Dilnot in 2011) would cost £3.6 billion by 2035, and that rolling out a minimum level of social care to all older people with high needs and limited resources would cost a similar amount.
The new study, administered by the Linus Pauling Institute at Oregon State University and published in the December 2018 issue of The Journal of Nutrition, found that older adults who added hazelnuts to their diet for 16 weeks significantly improved their levels of two key micronutrients. Results showed increased blood concentrations of magnesium and elevated urinary levels of a breakdown product of alpha tocopherol, commonly known as vitamin E.
While other animal embryos grow outside the mother, their embryonic cells can get right to work accepting assignments, such as head, tail or vital organ. By contrast, mammalian embryos must first choose between forming the placenta or creating the baby. New research at MSU has pinpointed two proteins that are the keys to this decision making. The process of assigning cells to placenta or baby is important because that is when pluripotent cells are made. These adaptable pluripotent cells are critical to stem cell research.
Use of two episodic memory tests help in predicting brain atrophy and Alzheimer's disease, as indicated by a study carried out at the University of Helsinki and the University of California. Researchers suggest that comprehensive use of memory tests could improve the diagnosis of mild cognitive impairment due to Alzheimer's disease.
Researchers at Johns Hopkins Medicine have identified in live human brains new radioactive 'tracer' molecules that bind to and 'light up' tau tangles, a protein associated with a number of neurodegenerative diseases including Alzheimer's disease and other related dementias.
Researchers have discovered what might be an effective strategy to prevent and combat cognitive dysfunction in obese individuals. They are the first to examine the modulatory role of an exercise-induced protein in the brain that promotes neuron survival and used high-intensity interval exercise (HIIE) in obese and normal-weight subjects. Obesity reduces the expression of this protein and lower levels are associated with Alzheimer's, Parkinson's and obesity. HIIE upregulated this protein in the obese subjects compared to normal-weight subjects.
A scientific strategy that explores therapeutic targets based on the biology of aging is gaining ground as an effective approach to prevent and treat Alzheimer's disease, according to research published in the December 7, 2018 online issue of Neurology®.