In Alzheimer's disease, impaired blood flow to brain regions coincides with tau protein buildup. This relationship strengthens as cognition declines, according to new research published in JNeurosci.
This tool is able to identify single-person neurodegeneration before the symptom's appearance, which could significate a more effective and personalized medicine.
Melbourne researchers are working towards a potential treatment to slow the progression of motor neuron disease (MND). The research team have uncovered how inflammation in MND is triggered. Pinpointing the molecules involved in this pathway could be a first step towards a new treatment for MND.
A McGill-led multi-institutional research team has discovered that during memory consolidation, there are at least two distinct processes taking place in two different brain networks - the excitatory and inhibitory networks. The excitatory neurons are involved in creating a memory trace, and the inhibitory neurons block out background noise and allow long-term learning to take place.
There are concerns that exposure to general anesthesia during surgery may contribute to an increased risk of Alzheimer's disease. To investigate, researchers compared exposure to general anesthesia versus regional anesthesia during elective surgery, looking for potential links to the development of dementia.
Recognizing the need for improved imaging capabilities, a group of scientists from the Hong Kong University of Science and Technology (HKUST) focused their sights on achieving brain imaging at synaptic resolution.
Sanford Burnham Prebys Medical Discovery Institute today announced that two faculty members, Peter Adams, Ph.D., and Jerold Chun, M.D., Ph.D., have received National Institutes of Health (NIH) Director's Transformative Research Awards. The awards, which total $8.5 million and are two of only nine granted in 2020, come from the NIH Common Fund's High-Risk, High-Reward Program.
After examining the brainstems of 186 young Mexico City residents aged between 11 months and 27 years of age, researchers, including Professor Barbara Maher from Lancaster University, found markers not only of Alzheimer's disease, but also of Parkinson's and of motor neurone disease (MND) too. These markers of disease were coupled with the presence of tiny, distinctive nanoparticles within the brainstem - their appearance and composition indicating they were likely to come from vehicle pollution.
People with atrial fibrillation have a reduced risk of dementia if they undergo a procedure called catheter ablation to restore the normal rhythm of their heart, according to a new study published in the European Heart Journal that analyses over 27,000 patients with newly diagnosed atrial fibrillation out of a population of nearly a million people.
MIT researchers find that astrocytes with the risk-increasing APOE4 variant show deficits of key cellular function called endocytosis, but overexpressing another Alzheimer's associated gene, PICALM, overcame the defect