Epilepsy is a common neurological condition with a prevalence of around 2 percent. Many antiepileptic drugs are available to prevent epileptic seizures, allowing up to 80 percent of patients to become seizure-free. However, previous research has found a positive association between the use of AEDs and dementia.
A new method uses fluorescence to detect potentially disease-causing forms of proteins as they unravel due to stress or mutations.
Love can make us do crazy things. It often prompts us to behave in counterintuitive ways, like, for example, placing the wellbeing of our loved ones above our own. But why?
By discovering the culprit behind decreased blood flow in the brain of people with Alzheimer's, biomedical engineers at Cornell University have made possible promising new therapies for the disease.
Aggregates of the protein tau are a hallmark of Alzheimer's disease. Researchers studying how these fibrils form have been unable to explain why different sizes appear in disease based on what we know about how they grow. Now, researchers have discovered that instead of adding just one protein at a time, fibrils can join end-to-end to create one longer cable. The finding may help researchers understand how drug candidates designed to delay tau aggregation work.
Before the age of GPS, humans had to orient themselves without on-screen arrows pointing down an exact street, but rather, by memorizing landmarks and using learned relationships among time, speed and distance. They had to know, for instance, that 10 minutes of brisk walking might equate to half a mile traveled. A new Johns Hopkins study found that rats' ability to recalibrate these learned relationships is ever-evolving, moment-by-moment.
Using a novel mouse model, Joslin researchers demonstrate that impaired insulin signaling in the brain negatively affects cognition, mood and metabolism, all components of Alzheimer's disease.
A hormone called irisin -- produced during exercise -- may protect neurons against Alzheimer's disease.
New research reveals RNAs, which are crucial for cells to produce proteins, are also involved in protein aggregation, where proteins do not fold properly and 'clump' together into aggregates.
A simple combination of molecules converts cells neighboring damaged neurons into functional new neurons, which could potentially be used to treat stroke, Alzheimer's disease, and brain injuries.