Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans. Looking at the brain cells of aging flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans.
Scientists have uncovered new clues implicating a type of herpes virus as the cause of a central nervous system disease in monkeys that's similar to multiple sclerosis in people. By linking two specific T cells to the loss of myelin, scientists say the new study opens the possibility of developing an antiviral therapy that could be especially useful for newly diagnosed cases of multiple sclerosis.
COLUMBIA, Mo. - When he was in middle school, teachers would give Sam Curran a list of words to type in a computer to practice his vocabulary.
A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body.
A new study conducted at the University of Turku, Finland, shows that patients with a schizophrenia spectrum disorder have an increased risk of Parkinson's disease later in life. The increased risk may be due to alterations in the brain's dopamine system caused by dopamine receptor antagonists or neurobiological effects of schizophrenia.
Editors of the Journal of Clinical Sleep Medicine have identified some of the most significant articles in the publication's history, publishing new commentaries on them in a special 15th anniversary collection. The 15 commentaries from associate editors and members of the journal's editorial board describe the impact of the selected articles both at the time of their publication and today.
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn't respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don't target.
Researchers from the PTSD Systems Biology Consortium identified distinct biotypes for post-traumatic stress disorder, the first of their kind for any psychological disorder. These biotypes can refine the development of screening tools and may explain the varying efficacy of PTSD treatments. PTSD diagnosis is complicated by over-reliance on self-reporting of patient symptoms, particularly underreporting signs of distress due to perceived stigma. Researchers identified two PTSD biotypes with differing genetic markers and underlying mechanisms of disease.
Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1). The results of the Phase 2 clinical trial, co-chaired by Michael J. Fisher, MD at CHOP, were published recently in Nature Medicine.
Researchers from the University of Cambridge, the University of Milan and Google Research have used machine learning techniques to predict how proteins, particularly those implicated in neurological diseases, completely change their shapes in a matter of microseconds.