An elevated pre-pregnancy hemoglobin A1c--which measures average blood glucose concentration--is associated with a higher risk of adverse pregnancy outcomes even in women without known diabetes, according to a new study published this week in PLOS Medicine by Joel Ray of ICES and the University of Toronto, Canada, and colleagues.
Metabolite signature composed of sugars, amino acids and lipids can predict with over 85 per cent accuracy whether a women will develop diabetes after pregnancy marked with gestational diabetes.
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease often associated with diabetes. However, it is unclear how NASH develops and there is currently no approved medication for the disease. A research group including Members of Kobe University's Graduate School of Medicine has clarified the mechanism behind NASH and diabetes. It is hoped that the pathway uncovered in this study will provide potential target for the development of new medications for these conditions.
Researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery, according to a retrospective study published online in Obesity, the flagship journal of The Obesity Society.
Researchers of Universitat Rovira I Virgili and Harvard Medical School have demonstrated the association between the consumption of omega 3 and the reduction in the risk of suffering cardiovascular events through the analysis of lipoprotein samples from 26,034 women, the largest and most detailed study ever carried out.
New findings published in the Journal of Internal Medicine reveal altered gene expression in fat tissue may help explain why individuals who have regained weight after weight loss surgery still experience benefits such as metabolic improvements and a reduced risk of type 2 diabetes.
University of Melbourne researchers have quantified the toll that having multiple chronic diseases takes in China for the first time, which could have significant implications for its economic and health systems. Researchers say is also timely as COVID-19 has placed further pressure on the public health emergency management system in China.
In a study publishing May 21 in the journal Cell, researchers use a genetic database of more than 47,000 people in Estonia to identify a gene linked to thinness that may play a role in resisting weight gain in metabolically healthy thin people. They show that knocking out this gene results in thinner flies and mice and find that expression of it in the brain may be involved in regulating energy expenditure.
A newly identified biomarker could help scientists pinpoint which cancers are vulnerable to treatment with biguanides, a common class of medications used to control blood sugar in Type 2 diabetes.
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in Europe and the United States. DZD researchers have now discovered new genes that play a role in the development of fatty liver. In humans and mice, respectively, the genes IRGM, Ifgga2 and Ifgga4 are responsible for the production of regulatory proteins of the family of immunity-related GTPases which counteract fat accumulation in the liver. The results have now been published in the Journal of Hepatology.