Patients with well-supported immune cells in their tumors are more likely to control their cancers' growth for a longer time, an observation that could guide treatment decisions after surgery for kidney cancer. In addition, the findings could help researchers expand the dramatic but sparse benefits of cancer immunotherapy to more people.
A prescription of short-term exercise for patients with advanced prostate cancer could help to reduce the side-effects of hormone therapy, according to new research. The trial aimed to reduce the adverse side-effects of hormone therapy such as weight gain and an increased risk of heart problems. The results show that a three month programme of aerobic and resistance training intervention prevented adverse changes in cardiopulmonary fitness and fatigue
A novel MRI-guided procedure that uses therapeutic ultrasound effectively treats prostate cancer with minimal side effects, according to a new study. Researchers said the incision-free technique could also be used to treat benign enlargement of the prostate gland.
A new home urine test for prostate cancer could revolutionize diagnosis -- according to new research. As well as diagnosing aggressive prostate cancer, the test predicts whether patients will require treatment up to five years earlier than standard clinical methods. It also means that men don't have to come into the clinic to provide a urine sample -- or have to undergo an uncomfortable rectal examination.
Primary cilia are found on nearly all cell types and serve an important role in sensing external mechanical and chemical signals, likely through extracellular vesicles (EV) called ectosomes. Researchers at the Medical University of South Carolina found that disruption of the exocyst, a protein complex required for cilia production, led to short or absent cilia and a concomitant reduction in EV release, likely resulting in changes in intercellular communication.
A transcription factor that aids neuron function also appears to enable a cell conversion in the prostate gland that can make an already recurrent cancer even more deadly, scientists say.
Whether a higher or lower dose of the muscle relaxant baclofen was associated with 30-day risk of hospitalization with encephalopathy (defined as a main diagnosis of delirium, disorientation, transient alteration of awareness, transient ischemic attack or an unclear diagnosis of dementia) among newly prescribed patients with chronic kidney disease was the focus of this observational study with nearly 16,000 older adults.
Data from about 5 million people (with and without diabetes) in 28 countries were used to develop equations to help identify people at increased five-year risk of chronic kidney disease, defined as reduced estimated glomerular filtration rate (eGFR).
Researchers in this randomized clinical trial investigated if supplementation with vitamin D or omega-3 fatty acids compared with placebo over five years helped prevent the development or progression of chronic kidney disease among adults with type 2 diabetes. The main outcome measure was change in the glomerular filtration rate that was estimated from serum creatinine and cystatin C.
A plane has to be going pretty fast for a mere raindrop to crack its windshield, but it can happen. While scientists knew surface waves were behind the phenomenon, the details have long remained fuzzy. But thanks to new models of the physics behind the improbable feat, it may just help doctors crack kidney stones to pieces.