Researchers at UNC-Chapel Hill characterized the specific ways in which SARS-CoV-2 infects the nasal cavity to a great degree -- replicating specific cell types -- and infects and replicates progressively less well in cells lower down the respiratory tract. The findings suggest the virus tends to become firmly established first in the nasal cavity, but in some cases the virus is aspirated into the lungs, where it may cause more serious disease, including potentially fatal pneumonia.
A paper recently published online in the journal Chest reports on a study of the palliative ventilator withdrawal (PVW) procedure performed in intensive care units (ICU) at end of life.
Pod-based e-cigarettes' efficient delivery of nicotine may foster greater dependence than other types of e-cigarettes. Stronger health communication messages are needed around the consequences of using these devices.
A new study highlights the risks of pulmonary complications in patients with SARS-CoV-2 infection who undergo surgery, according to an observational study of 1,128 patients across 24 countries, published in The Lancet. The study was conducted between 1 January and 31 March 2020 and included data from hospitals mainly in Europe and America with ongoing SARS-CoV-2 infection outbreaks.
As if the COVID-19 pandemic isn't scary enough, the flu season is not far away. How severe will the flu season be as it converges with the COVID-19 outbreak? What can we do to prepare? Dr. Benjamin Singer, a Northwestern Medicine pulmonologist who treats COVID-19 patients in the intensive care unit, outlines the best defense against influenza, which also may protect against coronavirus.
The newest article in the American Journal of Roentgenology's open-access COVID-19 collection revealed a high frequency (77%) of negative chest CT findings among pediatric patients (n=30; 10 months-18 years) with COVID-19, while also suggesting that bilateral, lower lobe-predominant ground-glass opacities are common in the subset of children with positive CT findings. Consistent with reported symptomatology in children, the authors of this AJR article also observed a correlation between increasing age and increasing severity of findings.
Pairing a blood-thinning drug with aspirin daily for patients who have an angioplasty with a stent can contribute to better health outcomes, including lower risk of death, than aspirin alone, according to a recent study by cardiologists at the University of Alberta and Mazankowski Alberta Heart Institute.
Symptoms of posttraumatic stress disorder, depression, anxiety and insomnia among health care workers in Italy during the COVID-19 pandemic are reported in this observational study.
A systematic review of COVID-19 cases finds nearly half of patients reported changes to or complete loss of their sense of taste. The finding furthers the evidence that changes in taste are a valid screening tool for COVID-19.
LSU Health New Orleans pathologists performed the first series of autopsies on African Americans who died from COVID-19 in New Orleans, and their findings provide new and critical information to guide patient management. The findings are published in The Lancet Respiratory Medicine.