More people are being diagnosed with and dying from liver cancer in England than ever before, according to new research to be presented at the 2019 NCRI Cancer Conference. In 20 years, from 1997 to 2016, incidence and deaths from the most common form of the disease, hepatocellular carcinoma, have tripled and it is most common among the most deprived members of society.
Two new studies support and inform the use of proton radiation therapy to treat patients with hepatocellular carcinoma (HCC), a common but often fatal type of liver cancer for which there are limited treatment options. The studies were published in the International Journal of Radiation Oncology * Biology * Physics, the flagship scientific journal of the American Society for Radiation Oncology (ASTRO).
Cleveland Clinic has successfully performed the Midwest's first purely laparoscopic living donor surgery for liver transplantation in an adult recipient. The advanced procedure is available at only a few hospitals worldwide, and Cleveland Clinic is the second US academic medical center to offer this approach for living donor liver transplantation.
A safer and more sensitive contrast dye for MRI tests developed by a team led by Georgia State University researchers may provide the first effective, noninvasive method for detecting and diagnosing early-stage liver diseases, including liver fibrosis. Tests in animal models show the protein-based contrast agent, ProCA32.collagen1, can detect the early stage of alcohol-induced liver fibrosis and Non-Alcoholic SteatoHepatitis, which is the most severe form of non-alcohol fatty liver disease.
Researchers from Charité - Universitätsmedizin Berlin have developed a new diagnostic technique which enables the grading of tumor consistency using magnetic resonance imaging (MRI). The researchers used an imaging technique known as tomoelastography to visualize the mechanical properties of liver tumors. Results from this research have been published in Cancer Research*.
An article published ahead-of-print in the January 2020 issue of the American Journal of Roentgenology has identified sonographic biomarkers that can predict eventual malignant transformation of pathologically confirmed cirrhotic nodules for patients at risk for hepatocellular carcinoma (HCC). These additional imaging features may have the potential to be adopted as ancillary or even major features to stratify probability for HCC in the contrast-enhanced LI-RADS system.
Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies.
New insights into the journey from health to disease in the human liver have been made by scientists at the Wellcome Sanger Institute, Cancer Research UK Cambridge Institute, the University of Cambridge and their collaborators. In the largest study of its kind, the team documented in unprecedented detail how the accumulation of changes in our DNA over time, known as mutations, evolves during the development of chronic liver disease and liver cancer.
Researchers have discovered that a key cell type involved in liver injury and cancer consists of two cellular families with different origins and functions.
Mose model shows that SOX9 gene influences the severity Alagille syndrome.