A tiny arms race between bacteria and the viruses that attack them inside the gut could eventually offer a new way to treat out-of-balance microbiomes.
In a world first, Monash University researchers have identified a key biomolecule that enhances the repair of your gut lining by prompting stem cells to regenerate damaged tissue.
Researchers from the University of Melbourne and St Vincent's Hospital in Australia have conducted a trial involving 144 patients to compare the effectiveness of a multidisciplinary clinic - involving gastroenterologists, dieticians, psychiatrists and physiotherapists - with usual gastroenterology specialist-only care.
UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.
The individual mix of microorganisms in the human gastrointestinal tract provides vital clues as to how any future incidence of type 2 diabetes can be predicted, prevented and treated. This is demonstrated in a population study led from the University of Gothenburg, Sweden.
Based on their experience treating COVID-19, Columbia physicians have assembled critical information about the coronavirus's effects on organs outside the lungs.
A suite of articles in The Journal of Infectious Diseases contains the first swath of important data from the world's largest study of cardiovascular disease (CVD) prevention in people with HIV.
Scientists from the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) at the University of Saskatchewan (USask) and Temple University (Philadelphia, US) have demonstrated that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals.
Researchers have added fresh evidence that early exposure to vaccine-, bacterial- or microbiota-derived antigens has a dramatic effect on the diversity of antibodies an adult mammal will have to fight future infections by pathogens. This antibody diversity is called the clonal repertoire -- basically different single cells with distinct antibody potential that can multiply into a large clone of cells, all producing that distinct antibody.
Researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) show that in mice infected with Salmonella enterica Typhimurium - a common cause of food-borne diarrheal illness - curli amyloid provokes the generation of autoantibodies and joint inflammation. The most damaging of these effects were linked to systemic exposure to curli, revealing a hidden harm inflicted by bacterial components that escape the intestinal tract.