The new discovery could have important implications for brain infections, neurodegenerative diseases and autoimmune disorders.
Tumours found to evade the immune system by telling immune cells to produce immunosuppressive steroids. Researchers discovered that immune T cells from mouse skin and breast tumours secrete steroids, and that preventing this steroid production reduced growth of tumours in mice. The study found that either removing a key steroid-producing gene, or switching it off with a drug, dramatically slowed the formation or progression of cancers, revealing potential immunotherapy drug targets.
A leading COVID-19 vaccine candidate, developed at Beth Israel Deaconess Medical Center, creates the groundwork for a newly launched COVID-19 vaccine clinical trial.
Melbourne researchers have revealed the multiple, intertwined cell death systems that prevent the spread of the 'intracellular' bacterium Salmonella, an important cause of typhoid fever which kills more than 100,000 people annually.
To determine immunity to Sars-Cov-2 and the effectiveness of potential vaccines, the amount of neutralising antibodies in the blood of recovered or vaccinated individuals must be determined. A traditional neutralisation test usually takes two to three days and must be carried out with infectious coronaviruses in a laboratory complying to biosafety level 3. A Swiss-German research team has launched a test that takes only 18 hours and doesn't have high biosafety requirements.
Researchers at the MPI of Immunobiology and Epigenetics in Freiburg, Germany, and the University of Washington in Seattle, USA, for the first time, investigate the phenomenon of sexual parasitism in deep-sea anglerfish. The scientists show that this very rare mode of reproduction is associated with the loss of adaptive immunity. In the course of evolution, however, the animals have reorganized their immune systems and only survive with the help of their innate immunity.
Black and Hispanic pregnant women in Philadelphia are five times as likely as white and Asian women to have been exposed to the novel coronavirus, according to a new study led by Scott Hensley, Ph.D., an associate professor of Microbiology in the Perelman School of Medicine at the University of Pennsylvania, and Karen Marie Puopolo, MD, PhD, an associate professor of Pediatrics and neonatologist at the Children's Hospital of Philadelphia.
A treatment for multiple myeloma that harnesses the body's cancer-fighting T cells was safe in humans and showed preliminary signs of effectiveness, according to a clinical trial involving 23 patients with relapsed or treatment-resistant disease.
Researchers have developed a potential treatment for yellow fever. The drug, a purified antibody that targets the virus, has shown success in early-stage clinical trials in Singapore. It was developed by an international team led by MIT Professor Ram Sasisekharan.
A study led by Charité - Universitätsmedizin Berlin and the Max Planck Institute for Molecular Genetics (MPIMG) shows that some healthy individuals possess immune cells capable of recognizing the novel coronavirus, SARS-CoV-2. The reason for this might be found in prior infections with 'common cold' coronaviruses. Whether or not this cross-reactivity has a protective effect on the clinical course in individuals infected with SARS-CoV-2 will now be addressed by the 'Charité Corona Cross' study.