In the largest study to date of proteins related to Alzheimer's disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers. The findings suggest that sets of proteins that regulate glucose metabolism, together with proteins related to a protective role of astrocytes and microglia -- the brain's support cells -- are strongly associated with Alzheimer's pathology and cognitive impairment.
Scientists report that the combined effects of rare, damaging mutations present at birth have a negative impact on healthspan and longevity, according to a study published this week in eLife.
Physicians from Sapienza University in Rome have published promising results of a small prospective interventional trial using noninvasive pulsed electromagnetic field therapy (PEMF) to treat men suffering from benign prostatic hyperplasia (BPH). After one month of treatment, prostate volume and symptoms significantly decreased. Men with moderate-severe lower urinary tract symptoms and without metabolic syndrome benefited more from the treatment. The study was recently published in Andrology, the highest ranked journal of andrological research.
New research from McGill University has found that the presence and severity of mild behavioral impairment (MBI) in cognitively healthy individuals is strongly associated with the presence of amyloid plaques deposits in the brain, a hallmark of Alzheimer's disease.
The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer's and Parkinson's.
In a policy brief published today in its namesake journal (DOI: 10.1111/jgs.16477), the American Geriatrics Society (AGS) offered a roadmap to guide federal, state, and local governments addressing COVID-19 concerns for a critical--and critically impacted--group: Older adults in nursing homes and long-term care.
Scientists have identified the genetic switches regulating knee development in mouse and human, explored their evolution, probed their links to bipedalism and osteoarthritis, and confirmed that a mutation in one switch gives rise to the disease. The findings could lead to screening for subtle shape alterations and genetic variations earlier in life that might predispose a person to risk. The methods could be used to explore genetic links between any advantageous trait and potential pathology.
Japanese researchers have found that elderly carriers of a specific DsbA-L gene type are at increased risk for lung function decline. The protein DsbA-L is known to be an antioxidant and enhances the function of the beneficial protein adiponectin. Decreased expression of the DsbA-L gene in lung tissue resulted in an increase in oxidative stress and mucous production. The researchers expect that precision medicine focusing on this gene will prove to be beneficial.
The first paper from the NIH-funded A4 study supports the hypothesis that higher levels of amyloid protein in the brain represent an early stage of Alzheimer's disease. Screening data for the study show that amyloid burden in clinically normal older adults is associated with a family history of disease, lower cognitive test scores, and reports of declines in daily cognitive function.
Fifteen blood metabolites are key for diagnosing the age-related disorder, frailty, new study finds.