The study undertook a genome-wide search for variants influencing how long participants' parents lived. The team studied 389,166 volunteers who took part in the UK Biobank, with confirmation in the US Health and Retirement Study and the Wisconsin Longitudinal Study. Eight genetic variants had already been linked for lifespan, mainly involved in heart disease and dementia. The latest study, published in the journal Aging NY, has expanded this to 25 genes in all, with some specific to mothers' or fathers' lifespan separately.
Researchers at the University of Connecticut, University of Exeter, University of Wisconsin and University of Iowa studied 389,166 volunteers who gave DNA samples to the UK Biobank, US Health and Retirement Study and the Wisconsin Longitudinal Study. In addition to confirming the eight genetic variants that had already been linked to longevity, this study found 17 more to expand the list of known variants affecting lifespan to 25 genes, with some sex-specific.
When people retire from work life, they sleep approximately 20 minutes longer than before retirement. The quality of sleep also improves, as retired people experience less early morning awakenings or non-restorative sleep, unlike in their last working years.
The IDS-TILDA Wave 3 report shows increased rates of health screening, contrasted by increases in chronic health conditions and emerging social isolation issues.
About 15 million Americans will have either Alzheimer's dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year. The findings highlight the need to develop preventive measures that could slow the progression of the disease in at risk for Alzheimer's dementia.
A study published online today in Science, led by researchers from Boston Children's Hospital and Harvard Medical School, used whole-genome sequencing of individual neurons and found strong evidence that brain mutations accumulate as we age. They also found that mutations accumulate at a higher rate in people with genetic premature aging disorders causing early brain degeneration.
Researchers describe a new approach to prevent death in essential kidney cells during kidney disease. Studying multiple animal models of kidney disease, the team discovered a compound that can impede loss of the filtration cells and restore kidney function. The work, inspired by an investigation into a genetic form of the condition, has the potential to affect therapeutic research for millions of people suffering from progressive kidney diseases.
Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Working in flies and mice, researchers discovered that TOR, a nutrient sensing pathway which is central to the aging process, drives the loss of adult stem cells. Treating mice with the TOR-inhibitor rapamycin prevented this loss and could reverse age-related loss of stem cells in mouse trachea.
Playing 3-D platform video games on a regular basis may improve cognitive functions in seniors and increase grey matter in a brain structure called the hippocampus, an Université de Montréal study suggests.
Newly emerging trends in data suggests humans may have reached their maximum limits for height, lifespan and physical performance. These biological limitations may be affected by anthropogenic impacts on the environment -- including climate change -- which could have a deleterious effect on these limits. This review is the first of its kind spanning 120 years worth of historical information, while considering the effects of both genetic and environmental parameters.