Replacing the popular contraceptive shot known as DMPA with alternative methods of contraception could help protect women in sub-Saharan Africa and other high-risk regions from becoming infected with HIV, according to a comprehensive review of available evidence published in the journal Endocrine Reviews.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has published appropriate use criteria (AUC) for somatostatin receptor PET imaging in neuroendocrine tumors. This AUC is part of a new series developed by SNMMI in its role as a qualified provider-led entity (PLE) under the Medicare Appropriate Use Criteria Program for Advanced Diagnostic Imaging. The AUC for somatostatin receptor PET imaging addresses several clinical scenarios for diagnosing neuroendocrine tumors (NETs).
The scent of a romantic partner can help lower stress levels, new psychology research from the University of British Columbia has found. Women feel calmer after being exposed to their male partner's scent, but being exposed to a stranger's scent had the opposite effect and raised levels of the stress hormone, cortisol.
Transitioning away from a popular contraceptive shot known as DMPA could help protect women in Sub-Saharan Africa and other high-risk regions from becoming infected with HIV, according to a research review published in the Endocrine Society's journal Endocrine Reviews.
A study in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long-term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with type 1 diabetes. The researchers used an adeno-associated viral (AAV) vector to deliver to the mouse pancreas two proteins, Pdx1 and MafA, which reprogrammed plentiful alpha cells into functional, insulin-producing beta cells.
In an effort to reduce the associated increased risk of heart disease after hysterectomy, more surgeons are opting to leave a woman's ovaries intact. However, a new study shows that women (especially those aged younger than 35 years) having a hysterectomy with ovarian conservation are still at increased risk. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
A new approach to reducing bulging tummy fats has shown promise in laboratory trials. It combines a new way to deliver drugs, via a micro-needle patch, with drugs that are known to turn energy-storing white fat into energy-burning brown fat.
Postpartum depression strikes nearly one in five new mothers. Stress is a significant risk factor for this complex condition. Tufts University neuroscientists have generated a novel preclinical model of postpartum depression and demonstrated involvement of the hypothalamic-pituitary-adrenal axis (the neuroendocrine system that mediates physiological response to stress and is normally suppressed during and after pregnancy). These findings in mice provide the first empirical evidence that disruption of this system engenders behaviors mimicking human postpartum depression.
A team led by University of Illinois food science and human nutrition professor Zeynep Madak-Erdogan found that treating ovariectomized mice with a combination of conjugated estrogens and the drug bazedoxifene improved metabolism and prevented the weight gain often associated with low estrogen levels without posing increased risk to their reproductive tissues.
In a pair of publications, researchers have shown how cells adapt to stressors -- like water loss -- by reprogramming their internal signaling networks. The studies describe previously unknown mechanisms that cells use to send signals between cellular machinery and avoid cell death. According to the authors, drugs that enhance the adaptation mechanisms could help cells stave off multiple diseases, including type 2 diabetes. The studies were published in Cell Reports and Molecular Cell.