Researchers compared mortality and severe adverse events in this systematic review and meta-analysis of 52 studies that evaluated clinical outcomes among nearly 102,000 patients with COVID-19 who did and didn't receive angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs).
Scientists have discovered that tracking malaria as it develops in humans is a powerful way to detect how the malaria parasite causes a range of infection outcomes in its host. The study, found some remarkable differences in the way individuals respond to malaria and raises fresh questions in the quest to understand and defeat the deadly disease.
Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.
A team of researchers led by UCL Great Ormond Street Institute of Child Health (ICH) and Great Ormond Street Hospital (GOSH) has found that metformin - a drug commonly used to treat Type 2 diabetes - can successfully reduce symptoms associated with tuberous sclerosis complex (TSC), including reduction in the frequency of seizures and the size of brain tumours.
GlyNAC - a combination precursors of the natural antioxidant glutathione - improved many age-associated defects in older humans boosting muscle strength and cognition.
This comparative effectiveness study investigates how the COVID-19 pandemic is associated with the benefits and risks of standard radiation therapy in simulated patients.
Among patients who return to work after a heart attack, those who work more than 55 hours per week, compared to those working an average full-time job of 35-40 hours a week, increase their odds of having a second heart attack by about twofold, according to a prospective cohort study published today in the Journal of the American College of Cardiology.
A study of more than 56,000 patients with valvular atrial fibrillation in the United States found that new users of direct oral anticoagulants (DOACs) had lower risks for ischemic stroke or systemic embolism and major bleeding events, compared with new users of warfarin. Results from a comparative effectiveness study are published in Annals of Internal Medicine.
In a new open-access Guidelines & Guidance paper published in PLOS Medicine, Matthew Page of Monash University, Melbourne, Australia and co-authors present PRISMA 2020, an updated version of the Preferred Reporting Items for Systematic reviews and Meta-Analyses reporting checklist. The new guideline paper is also being published in the British Medical Journal, Journal of Clinical Epidemiology, Systematic Reviews and International Journal of Surgery.
Clinical activity with a second drug inhibiting KRASG12C confirms its role as a therapeutic target in patients with advanced non-small-cell lung cancer (NSCLC) harbouring this mutation, according to results from a study with the KRASG12C inhibitor adagrasib reported at the European Lung Cancer Virtual Congress 2021.