A new computational tool developed by researchers from Purdue University and MIT could help better determine which drugs should move from animal testing to humans. It could also sooner detect a reason why a drug might fail, guiding how a clinical trial should be set up.
Findings from a research study led by scientists at Henry Ford suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway. Histone deacetylases (HDACs) are enzymes that help modulate gene expression by removing acetyl groups from histone or non-histone proteins. Inhibition of HDACs is emerging as a promising approach to treat various types of malignant diseases and inflammatory disorders.
A new study presented today at the Society of NeuroInterventional Surgery's (SNIS) 17th Annual Meeting serves as the first prospective validation of the Rapid Arterial Occlusion Evaluation (RACE) scale in accurately identifying a severe clot stroke called a Large Vessel Occlusion (LVO) by U.S.-based EMS personnel in a pre-hospital setting.
An early blood test could detect which babies deprived of oxygen at birth are at risk of serious neurodisabilities like cerebral palsy and epilepsy.
A potentially safer, more effective chemotherapy treatment for patients with blood-related cancers, such as leukemia, who need a particular bone marrow transplant procedure is under study at the University of Arizona Health Sciences. The procedure is known as a haploidentical (half-matched) bone marrow transplantation, or "haplo-BMT," providng an alternate source of stem cells for patients needing a bone marrow transplant but unable to find a perfect or near-perfect donor match for human leukocyte antigens.
A test which detects changing levels of tumour fragments in the blood may be an easy, non-invasive and quick way to predict who will benefit from immunotherapy, a treatment option for advanced cancers.
Professor Shabir A. Madhi of the University of the Witwatersrand, Johannesburg, is the lead author of a study published in the prestigious New England Journal of Medicine on Thursday, 30 July 2020. The multinational, multicentre study reports on the first RSV vaccine to provide evidence that inmunisation of pregnant woman could protect young infants under six months old against severe RSV lower respiratory tract infection (LRTI).
A new "mathematical language" to classify seizures in epilepsy could lead to more effective clinical practice, researchers from Europe, the US, Australia and Japan propose in a new publication in eLife. An epilepsy model developed by the Human Brain Project provides the basis for the novel framework, which could also push forward basic understanding of the disease.
Is the long-term use of glucocorticoids essential in people with chronic inflammatory diseases such as rheumatoid arthritis, or can early discontinuation prevent characteristic side effects? How can these drugs be discontinued without giving rise to glucocorticoid withdrawal syndrome? These were the questions addressed by the SEMIRA study, a large European trial led by Charité - Universitätsmedizin Berlin.
A new study published today in Lancet Public Health has found that front-line healthcare workers with adequate personal protective equipment (PPE) have a three-fold increased risk of a positive SARS-CoV-2 test, compared to the general population.