Dr. Wylie, director of the Ortenzio Center, commented on the results of this task-based functional neuroimaging paradigm: "Our findings provide further evidence for a functionally connected 'fatigue network' in the brain. More importantly, we have shown for the first time that this functional network connectivity changes in association with cognitive fatigue," he emphasized. "This promises to accelerate progress toward effective interventions aimed at relieving debilitating fatigue."
Tocilizumab, an anti-inflammatory drug used to treat rheumatoid arthritis, improves outcomes in severely ill COVID-19 patients, finds the results of a new trial conducted in hospitals across India -- one of the world's most ethnically diverse countries.
For the drug approval process in the United States, investigators have been expanding clinical trials to sites outside the country. However, a new study indicates that this trend may be widening racial disparities in patient enrollment in cancer clinical trials. The study is published by Wiley early online in CANCER, a peer-reviewed journal of the American Cancer Society.
After 'trying on' three placebo methods for the delivery of a rectal microbicide, study participants said they could see all of them - a douche, rectal suppository and fast-dissolving rectal insert - fitting into their daily lives. These results, which also identified the product attributes most important to participants, underscore the importance of developing a range of HIV prevention products for people who practice anal sex.
Strong, collaborative relationships with principal investigators are a key factor of longevity in clinical research coordinator positions -- an essential, but increasingly transient job in executing treatment-advancing clinical trials, Vanderbilt University Medical Center researchers found.
Less than one-third of COVID-19 clinical trials are led by women, which is half the proportion observed in non-COVID-19 trials, according to research led by Queen Mary University of London, University of St Andrews, Brigham and Women's Hospital and Harvard Medical School.
Texas A&M University College of Medicine ressearchers have recently discovered that cytisine -- a smoking cessation drug commonly used in Europe -- reduces the loss of dopamine neurons in females. These findings provide potential evidence for the use of the drug to treat Parkinson's disease or stop its progression in women.
This randomized clinical trials reports that among adults with mild COVID-19, a five-day course of ivermectin, compared with placebo, didn't significantly improve the time to resolution of symptoms. The findings don't support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand the effects of ivermectin on other clinically relevant outcomes.
For chronic pain sufferers an app may be just the tool they need to manage their pain. In a UHN-led study that used the app "Manage My Pain" enrolled patients saw clinically significant reductions in key areas that drive increased medical needs, potential abuse of prescription opioids and of course, pain.
Clinical trial registrations for COVID-19 interventions that were highly publicized during the COVID-19 pandemic compared with treatments not comparably promoted were assessed in this study.