Biomedical engineers at Duke University have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment. This marks the first time researchers have delivered CRISPR/Cas9 repressors for targeted therapeutic gene silencing in adult animal models.
You've heard of 'nature versus nurture,' and philosophers argue about which is more important. But how does this work on the cellular level?
Revised guidelines incorporating new data on discharge criteria for patients undergoing elective percutaneous coronary intervention (PCI) will allow for flexibility in length of stay while ensuring patient safety.
SCAI released new guidelines to address the selection of specific categories of devices when endovascular therapy (EVT) is indicated. The purpose of this document, which is the first of its kind, is to provide a review of comparative effectiveness data, including safety and efficacy of femoral-popliteal (FP) devices, and to provide clinicians with guidance and recommendations for device selection when these devices are intended as the definitive or adjunctive therapy.
After a heart attack, patients must create new heart muscle cells to heal. Harvard study shows that mice make more new heart muscle cells when they exercise compared to when they do not. This was true for both healthy mice and those that had experienced a heart attack. Findings demonstrate that one reason exercise is beneficial to health is that it increases the heart's capacity to regenerate.
Ideological debate over support for science sometimes pits 'curiosity-driven' against 'utilitarian' research. Drug-discovery scientists at Harvard and Novartis reviewed the evidence and historical records. Large body of evidence shows that fundamental science lays the essential foundation for developing the best medicines in the future.
A study led by Massachusetts General Hospital investigators may lead to a significant expansion in the number of stroke patients who can safely be treated with intravenous tPA, the 'clot busting' drug that has greatly reduced stroke-related disability and deaths in eligible patients.
Drinking kefir may have a positive effect on blood pressure by promoting communication between the gut and brain. Kefir is a fermented probiotic milk beverage known to help maintain the balance of beneficial bacteria in the digestive system. Researchers will present their findings today at the American Physiological Society (APS) annual meeting at Experimental Biology 2018 in San Diego.
Researchers at the University of Exeter have found a statistical link between pneumonia in older people and a group of medicines commonly used to neutralize stomach acid in people with heartburn or stomach ulcers. Although proton-pump inhibitors (PPIs) are still a valuable group of medicines, research is indicating that PPIs are not as completely safe for older people as previously thought.
Analysis of high-resolution genomic data in a large study population reveals novel low-frequency polymorphisms that drive response to dietary lipids and medication.