A new landmark study by researchers at the University of Maryland School of Medicine (UMSOM) found that patients with a vascular condition, called abdominal aortic aneurysm, received no benefits from taking a common antibiotic drug to reduce inflammation.
New research published in Experimental Physiology suggests that fire service instructors are at increased risk of cardiovascular diseases due to higher levels of inflammation in their blood, and so their exposure should be limited to nine exposures per month.
Extracellular ligand PEDF holds cell fate in its hands, inducing cell death or promoting survival depending on which host cell receptor it binds to. However, the spatiotemporal control of PEDF was unclear. Researchers led by Osaka University have now shown that PEDF binds to a specific lysine residue on type I collagen that is also involved in collagen crosslinking. Upon collagen remodeling, PEDF is gradually released, allowing it to interact with host cell receptors.
Atrial fibrillation ranks among the most common heart conditions, and episodes are difficult to predict. Researchers have proposed a way to define cardiac state and have studied the dynamics before the cardiac rhythm changes from normal sinus to AF rhythm and vice versa. The work, appearing in Chaos and based on critical transition theory, looks to provide an early warning for those with paroxysmal atrial fibrillation with potential implications for future wearable devices.
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time. Using the rat heart as a model, the investigators in this study -- appearing May 26 in the journal iScience -- created a comprehensive map of the intrinsic cardiac nervous system (ICN) at a cellular scale. This map lays the groundwork for developing virtual maps for other organs.
Higher spirituality was strongly linked to better quality of life for stroke survivors and their caregivers. The study emphasizes the importance of caring for stroke survivors holistically, as an individual with emotional needs and part of an interdependent unit with their caregivers.
Patients with heart failure who experience low health literacy are at an increased risk of hospitalization and mortality. This finding has significant clinical and public health implications and suggests that assessing and intervening upon an individual's understanding of their own health could improve heart failure outcomes, according to research published in JACC: Heart Failure.
The study, conducted in Switzerland, found that having multiple sleep-wake disturbances such as sleep-disordered breathing, extreme long or short sleep duration, insomnia and restless leg syndrome independently and significantly increased the risk of a new cardio-cerebrovascular event in the two years following a stroke.
University of Rochester researchers studied stroke patients who experienced vision loss and found that the patients retained some visual abilities immediately after the stroke but these abilities diminished gradually and eventually disappeared permanently after approximately six months. Early intervention in the form of visual training appears to stop this gradual loss of visual processing that stroke victims may experience. It is therefore important for occipital stroke patients to receive visual training early on after a stroke.
A research team led by investigators from Brigham and Women's Hospital has evaluated real-world evidence related to outcomes for COVID-19 patients who were treated with hydroxychloroquine or chloroquine analogues (with or without a macrolide). Investigators found no evidence that either drug regimen reduced the death rate among patients.