Oncotarget Volume 11 Issue 16 showed that the sensitivity of H1299 and A549 cells to concomitant treatment with PAC and WFA was greater than that of either PAC or WFA alone.
The cover for issue 16 of Oncotarget features Figure 6, 'Radiation-induced DNA damage measured by γ-H2AX foci formation at a specified time point after 10 Gy irradiation,' by Zhang, et al.
Early GP referrals are likely to lead to cancer patients surviving longer, a study by King's College London has found.
New data from a landmark study done by Monash University researchers in Australia raises significant concerns that even short-term exposure to low level air pollution can affect gene expression, leaving us at risk of other diseases such as cancer, cardiovascular and respiratory diseases. Research, published in the journal Environment International, provides the first evidence that exposure to even very low levels of air pollution can change gene expression that are the hallmark of diseases such as cancer.
Joint research between Kobe University and Ushio Inc. has provided proof for the first time in the world that direct and repetitive illumination from 222nm ultraviolet radiation C (UVC), which is a powerful sterilizer, does not cause skin cancer. This suggests that 222nm UVC is also safe for human eyes and skin. This could allow germicidal lamps to be shone directly on people's skin, enabling a wide range of antiviral and antibacterial applications in both medical fields and daily life.
Oncotarget Volume 11, Issue 12 reported outside its natural niche, the cultured prostate cancer stem cells lost their tumor-inducing capability and stem cell marker expression after approximately 8 transfers at a 1:3 split ratio.
Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.
With so much genetic information packed in such a tiny space, how cells access DNA when it needs it is something of a mystery. Research published today by Professor Joel Mackay and colleagues has revealed the role played by motor protein CHD4 that allows the DNA to remodel when the information is needed -- and it will help us understand diseases connected to when that process goes wrong.
The cover for issue 12 of Oncotarget features Figure 11, 'Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)' by Abdelfettah, et al.
Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem. The probability of relapse is significantly higher in the high-risk subset of patients undergoing treatment for APL; overall approximately 10-20% of APL patients relapse regardless of their risk stratification.