Free fatty acids in the blood are linked with higher rates of estrogen-receptor positive breast cancer in obese postmenopausal women, according to a new study led by food science and human nutrition professor Zeynep Madak-Erdogan at the University of Illinois.
Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones. In addition, they found that synthetic derivatives of stress hormones, which are frequently used as anti-inflammatory in cancer therapy, decrease the efficacy of chemotherapy. These results come from patient-derived models of breast cancer in mice and may have implications for the treatment of patients with breast cancer, as reported in Nature.
The genetic and molecular make-up of individual breast tumours holds clues to how a woman's disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a Cancer Research UK-funded study published in Nature.
An imaging technique used to detect some forms of cancer can also help detect preeclampsia in pregnancy before it becomes a life-threatening condition, a new Tulane study says.
Recent study formalizes the treatment strategy for this diagnosis, offering clear guidelines for plastic and oncologic surgeons.
A study of over 64,000 women of childbearing age in the USA has found that infertility is associated with a higher risk of developing cancer compared to a group of over three million women without fertility problems, although the absolute risk is very low at just 2 percent. The research is published in Human Reproduction journal.
UNC School of Medicine scientists uncovered a possible reason why some breast cancers are so aggressive and difficult to treat: an enzyme called USP21 promotes proliferation of basal-like breast cancer and is upregulated in a significant percentage of patient tumors. It could become a drug target.
Researchers have identified two new nuclear medicine tracers that make it easier to diagnose and potentially treat multiple types of cancer, providing high-quality images with less patient preparation and shorter acquisition times. The research is featured in the March issue of The Journal of Nuclear Medicine (http://jnm.snmjournals.org).
Australian and US researchers have developed a way to discover elusive cancer-promoting genes, already identifying one that appears to promote aggressive breast cancers. The University of Queensland and Albert Einstein College of Medicine team developed a statistical approach to reveal many previously hard-to-find genes that contribute to cancer. UQ Australian Institute of Bioengineering and Nanotechnology Associate Professor Jess Mar said the majority of 'oncogenes' identified to date were in most patients with a particular cancer type.
Researchers confirm the lower risk of breast cancer from multiple pregnancies and from breast feeding seen in average risk women extends to those at the highest risk of breast cancer, according to the largest prospective study of BRCA1 and BRCA2 mutations carriers to date. Women with BRCA1 mutations who had two, three or four or more full-term pregnancies were at 21 percent, 30 percent, and 50 percent decrease risk of breast cancer compared to women with a single full-term pregnancy.