Trying to understand why dormant breast cancer cells survive despite being starved of estrogen to prevent growth, researchers from Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center found that breakdown of fat to produce energy supports cancer cell survival. This type of fat metabolism is activated by metformin, an anti-diabetes drug being tested in clinical trials as an anti-cancer agent. Their findings suggest that metformin actually has context-dependent effects on cancer cells.
- Clinical Cancer Research
- National Institutes of Health, Mary Kay Foundation, Foundation for Women's Wellness, Friends of the Norris Cotton Cancer Center, Norris Cotton Cancer Center