Stanford chemists are developing new synthetic forms of a rare marine molecule that show promise for treating cancer and eradicating HIV.
A study led by Boston Children's Hospital and Massachusetts General Hospital demonstrates that a predictive computer model can identify patients at risk for attempting suicide from patterns in their electronic health records -- an average of two years ahead of time.
Cells infected with HIV make two forms of the virus's RNA. A new Science paper finds a single nucleotide controls which version of viral RNA an infected cell makes; both forms are necessary for HIV to replicate. The critical nucleotide happens to be in a region of the HIV genome with low mutation rates. That placement makes it a promising target for new therapies, because the virus is less likely to develop resistance.
A new study found that the majority of women living with HIV would endorse a monthly long acting injectable (LAI) antiretroviral therapy over current daily pills. LAI HIV therapy has completed Phase III trials and is awaiting Food and Drug Administration approval. Over half of the women would choose LAI HIV therapy over daily pills for convenience, privacy, and perceived effectiveness. This study is the first to exclusively explore women's interest in LAI HIV therapy.
In a New England Journal of Medicine paper, researchers urge a coordinated global effort in the face of the COVID-19 pandemic, with countries around the world [taking] concrete steps to assist Africa in staying ahead of the curve, even as they confront their own epidemics.
People living with HIV/AIDS are at increased risk of depressive disorders. But all too often, these conditions go unrecognized or untreated, suggests a literature review in the May/June issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Deaths of children and adolescents in China due to infectious diseases were becoming rare prior to the covid-19 pandemic, according to a new study.
People living with human immunodeficiency virus (HIV) infection are at higher risk of cardiovascular disease (CVD) compared to people without HIV. Data linking HIV and CVD, CVD risk factors and CVD risk assessment come predominantly from North America and Europe. However, of the estimated 37.9 million people living with HIV worldwide, two-thirds (25.6 million) live in sub-Saharan Africa, where less is known about rates of incident CVD and the burden of risk factors driving CVD risk.
HIV infection and replication within a human cell is a complex mechanism that involves multiple steps and several biochemical factors such as nucleic acids and proteins. Understanding the interplay between these factors has helped researchers to create drugs that target specific viral proteins to drastically slow down viral replication and effectively the progression of AIDS in patients.
Using a newly developed laboratory model of three types of brain cells, Penn and CHOP scientists reveal how HIV infection -- as well as the drugs that treat it -- can take a toll on the central nervous system.