Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now report in the journal Angewandte Chemie that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action. They developed small bifunctional molecules that simultaneously bind both chitin, a specific feature of the fungal cell wall and a molecule not found in humans, and naturally occurring human antibodies and redirect the human immune system to eliminate fungal pathogens.
A recently published paper in the Journal of Sex & Marital Therapy finds that US women report a diversity of preferences related to sexual pleasure and orgasm.
The answer to the question of why some organisms can regenerate major body parts while others, such as humans, cannot may lie with the body's innate immune system, according to a new study of heart regeneration in the Mexican salamander by James Godwin, Ph.D., of the MDI Biological Laboratory. Godwin found that formation of new heart muscle tissue after a heart attack is dependent on the presence of macrophages, a type of white blood cell.
A team of MIT chemical engineers, inspired by the way that cells translate their own mRNA into proteins, has designed a synthetic delivery system that is four times more effective than delivering mRNA on its own.
A new study published in the Annals of Neurology found a link between head trauma in adolescence, particularly if repeated, with a raised risk of later developing multiple sclerosis.
The International and American Associations for Dental Research (IADR/AADR) have published a special issue in the Journal of Dental Research (JDR) on orofacial clefting and dental and craniofacial anomalies. Topics in this special issue range from tooth number and root formation, human and animal genetic studies on orofacial clefting, reviews that prioritize the variants most likely to cause disease, the pathways required for palatogenesis, experimental articles on the periderm and drug therapy articles that rescue cleft palate in mutant mice.
As the embryonic brain develops, a complex cascade of cellular events occur, starting with progenitors -- the originating cells that generate neurons and spur proper cortex development. If this cascade malfunctions then the brain can develop abnormally. Eva Anton's lab at UNC has shown how the deletion of the protein APC in progenitor leads to massive disruption of brain development and the Wnt protein pathway, which previously was linked to genes associated with autism.
Communication breakdowns between care facilities can pave the way for outbreaks of infection, according to research on the spread of an extensively drug-resistant bacterium.
By studying rodents, researchers showed that instead of attacking germs, some neutrophils may help heal the brain after an intracerebral hemorrhage, a form of stroke caused by ruptured blood vessels. The study suggests that two neutrophil-related proteins may play critical roles in protecting the brain from stroke-induced damage and could be used as treatments for intracerebral hemorrhage.
A group of scientists led by Ramkumar Menon at The University of Texas Medical Branch at Galveston has gained new insights into what factors lead to preterm birth. This study is currently available in The American Journal of Pathology.