The current study demonstrates a deleterious effect of midazolam administration prior to myocardial ischemia and reveals reduced circadian protein Period 2 (PER2) levels as the underlying mechanism. These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancer nobiletin as preventative therapy for myocardial injury in the perioperative setting where midazolam pretreatment occurs frequently.
Adolescent THC exposure reduces the branching of prefrontal cortical neurons and the number of spines, which are critical for cellular communication. This adolescent exposure is also associated with a reorganization of the gene expression of specific genes that are predominantly related to neuron development, synaptic plasticity and chromatin organization (epigenetic mechanisms).
Somatic stem cells are microscopic workhorses, constantly regenerating cells throughout the body: skin and the lining of the intestine, for example. And to University of Illinois neuroscientists, they represent untapped potential.
Physicians are encountering a growing number of younger patients who are testing positive for hepatitis C virus (HCV) fueled largely by the opioid crisis impacting communities around the country. That increase and more effective and tolerable drug regimens for HCV infection, means one-time universal screening of all adults for HCV is now cost effective and recommended, say physician researchers in the University of Cincinnati (UC) College of Medicine.
Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice. Instead of killing causative bacteria with antibiotics, researchers treated infected mice with molecules that block toxin formation in bacteria. Every treated mouse survived. The breakthrough study, published in Scientific Reports, suggests infections in humans might be cured the same way.
With a few finger strokes or swipes on a computer or cell phone, seniors with pain reduce the risk of depression when visiting social media sites.
A subset of T cells contributes to the inflammation and bone loss that characterizes periodontitis, a severe form of gum disease. According to new research, led by the University of Pennsylvania's George Hajishengallis and scientists at the National Institutes of Health, drugs that specifically inhibit these cells may offer an effective therapy for the condition.
MIT researchers have shown that by delivering a combination of antibiotics and alginate-encapsulated probiotics, they can eradicate two strains of drug-resistant bacteria that often infect wounds.
New research finds that more bacterioplankton utilize vitamin B1 or B1 precursors from their environment than synthesize their own. The researchers also found that B1 availability can directly limit bacterioplankton growth, which could have larger impacts on aquatic microbial food webs, as well as energy and nutrient exchange.
Study finds significant changes in how seizure medications are metabolized during the different trimesters of pregnancy.