Experimenting in mice, the researchers tracked a series of events that enable a small reservoir of treatment-resistant cancer cells to awake from dormancy, grow and spread.
Awareness and diagnoses of hypertension and diabetes in China has been limited, resulting in compromised treatment, and increased screening did not lead to significant improvements, according to a new study. Until now, there was little information on how individuals with hypertension or diabetes in China first became aware of their conditions and what factors may have contributed to changes in awareness over time.
The federal right-to-try law's effect on the FDA, the gamification of science, how the Conscience and Religious Freedom Division is changing health care, and more in the latest issue.
Biologists have developed a computational model of flatworm regeneration to answer an important question in regeneration research - what are the signals that determine the rebuilding of specific anatomical structures? The model confirms experiments showing how numerous factors determine body pattern formation, and the critical role nerve fibers play in determining polarity in regeneration. The model could help understand regeneration in mammals, birth defects, and bioengineering of organoids.
A recent study led by Steve Davis, a researcher in the WVU School of Public Health, suggests fear of arrest is a formidable barrier to getting clean needles and disposing of used ones safely. That can make needle exchange programs less effective -- and hepatitis C infections more likely.
Mutations in a gene involved in brain development have led to the discovery of two new neurodevelopmental diseases by an international team led by researchers at McGill University and CHU Sainte-Justine Research Center.
In a study published in Cell, a team led by Dr. CHEN Lingling at the Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences (CAS) and Dr. YANG Li at the CAS-MPG Partner Institute for Computational Biology discovered that most examined circRNAs tend to form 16-26 bp intramolecularly imperfect RNA duplexes. In addition, circRNAs preferentially bind to dsRNA-activated protein kinase (PKR) which is related to innate immunity and act as PKR inhibitors.
A new study in the journal Psycho-Oncology, details how a seriously ill patient's optimism can impact a clinician's survival prognosis in palliative care conversations, impacting end-of-life decision-making and potentially, quality of life in the end-of-life setting.
Researchers from Boston University School of Medicine (BUSM) found that among all hospitalizations that were due to firearm injury, patients who underwent surgical repair of their major blood vessels had the highest injury severity score (predictor of in-hospital death).
Researchers at Nemours Children's Health System have developed a new low-cost genetic test that accurately identified more than 200 known disease-causing gene variations in two high-risk populations, the Old Order Amish and Old Order Mennonites of Lancaster County, Pennsylvania. The findings, published today in the Journal of Molecular Diagnostics, could help reduce morbidity and mortality from these rare genetic disorders, and dramatically reduce costs of care through early diagnosis of newborns.