Gene therapies have had success in treating blindness but can't save areas of the retina where cells have already died. In a new effort, University of Pennsylvania scientists John Wolfe, also of CHOP, and William Beltran, along with David Gamm of the University of Wisconsin-Madison, will attempt to develop a stem-cell-based approach that restores vision.
In new research, Antonella Caccamo and her colleagues explore a number of critical factors that appear to link the Down syndrome (DS) and Alzheimer's disease. In a new project, Caccamo will use DS as a window into the underlying mechanisms that may give rise to Alzheimer's pathology. Using this complementary approach, her $3.1 million NIH grant will explore the effects of a critical protein complex known as mTOR.
The University of Pennsylvania's Melanie Kornides, Jennifer Lewey, and C. Alix Timko, also of the Children's Hospital of Philadelphia, are pursuing research that examines the role of sex and gender on health. The work is supported by the Building Interdisciplinary Research Careers in Women's Health program.
Researchers at the U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (WRAIR) and SUNY Upstate Medical University in Syracuse, N.Y., have been awarded a grant to advance an experimental heroin vaccine through Phase I/IIa clinical trials to assess both its safety and its efficacy against a morphine challenge.
A new multi-university center led by Texas A&M University will contribute to our understanding of materials science fundamental to the maintenance of the United States' nuclear deterrent. It will also train the next generation of scientists and engineers who will ensure the safety, security and effectiveness of the nuclear weapons stockpile.
A University of Texas at Arlington computer science professor has received a $1.2 million grant from the U.S. Department of Education, supplemented with $300,000 in UTA matching funds, that will significantly increase the number of doctoral students, especially among women and minorities.
Toward ensuring that pregnant and postpartum women are properly screened, the Health Resources and Services Administration (HRSA) has recently awarded the RI Department of Health a five year, $650,000 per year grant in partnership with the Center for Women's Behavioral Health at Women & Infants Hospital.
UC San Diego receives $10.5 million from National Nuclear Security Administration to create new center of excellence, called the Center for Matters under Extreme Pressure.
Researchers hope the $100,000 project might result in establishment of an Engineering Research Center at KU to advance basic science that will underpin next-generation transport technology.
Researchers are now able to investigate the structural, cellular, and developmental intricacies of the human brain using bioengineered stem cell-based models called organoids. But ethics to help guide researchers and regulators lag behind the technological capability to 'grow' brains. A group of bioethicists and scientists will chart unexplored territory of neuroethics in a study called "The Brainstorm Project," led by Insoo Hyun, Ph.D.