In his new book 'Your brain knows more than you think,' the neuroscientist Professor Niels Birbaumer, a Senior Research Fellow at the Wyss Center, in Geneva, Switzerland, investigates the limitless capacity of the brain to remold itself.
Loyola Medicine psychiatrist Angelos Halaris, M.D., is co-editor of a major new publication examining how psychiatric disorders progress over time, and how this progression can be stopped.
'Prion Biology', published by CSHLP, examines the expanding roles of prions in health and disease. The contributors review the structures of prion proteins and how they adopt alternative structures and aggregate into amyloid fibrils and other insoluble complexes. The alternatively folded prion forms display unique biological properties. Although some prion proteins feature in cellular dysfunction, others have normal physiological roles (e.g., CPEB in the brain and MAVS in the immune response).
"The Biology of the TGF-β Family" provides a comprehensive view of the different members of the TGF-β family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF-β family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed.
"Cell Polarity", published by Cold Spring Harbor Laboratory Press, reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. Contributors discuss how cells coordinate signaling pathways, membrane trafficking, and cytoskeletal remodeling to ensure proper spatial arrangement of cellular components. Processes such as transcytosis, exocyst-mediated vesicle trafficking, and endosomal sorting are covered in detail.
Predicting the future, summoning angels and demons, creating talismans, dowsing rods and magic mirrors: In early modern times, magical rituals were part of the body of knowledge of the educated classes of society. Together with Dr. Bernd-Christian Otto, Professor Dr. Daniel Bellingradt examined a collection of 140 ritual magical manuscripts from the early 18th century which had previously remained undiscovered in the library of the University of Leipzig.
Dr. Indrajit Pal of the Asian Institute of Technology has co-edited a book titled 'Disaster Risk Governance in India and Cross Cutting Issues.' The 19-chapter book, published by Springer, provides an analytical discussion of the status of disaster risk reduction and governance in an Indian context.
"Tissue Engineering and Regenerative Medicine", published by Cold Spring Harbor Laboratory Press (CSHLP), surveys tools that are currently available to scientists and engineers in the field and how they have been used to fabricate physiologically appropriate tissues and organs. The contributors discuss the preparation of biologically active scaffolds that induce regenerative responses, three-dimensional bioprinting strategies to fabricate structures in preprogrammed patterns, and scaffold-free approaches using cells capable of self-assembly.
"The Biology of Exercise", published by Cold Spring Harbor Laboratory Press, examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered.
The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: cancer genes and genomes; cancer pathways; tumor cell biology; cancer growth & progression; innate & adaptive immune responses; and enabling technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.