A new pair of studies suggests that statins, drugs widely used to reduce cholesterol, may have a detrimental effect on the immune response to influenza vaccine and the vaccine's effectiveness at preventing serious illness in older adults. Published in The Journal of Infectious Diseases, the findings, if confirmed by additional research, may have implications for flu vaccine recommendations, guidelines for statin use around the time of vaccination, and future vaccine clinical trials in seniors.
In one of the new studies, researchers analyzed immune response data from an earlier flu vaccine clinical trial conducted during the 2009-2010 and 2010-2011 flu seasons. In the new study, funded by Novartis Vaccines, which also sponsored the original clinical trial, investigators focused on the potential effect of statin use on patients' initial immune responses after being immunized against flu. The analysis drew on data for nearly 7,000 adults over the age 65 in four countries, including the United States.
Statin users had a significantly reduced immune response to vaccination compared to those not taking statins, as measured by the level of antibodies to the flu vaccine strains in patients' blood three weeks after being vaccinated, the researchers observed. The effect was most dramatic in patients on synthetic statins, rather than naturally derived statins.
"Apparently, statins interfere with the response to influenza vaccine and lower the immune response, and this would seem to also result in a lower effectiveness of influenza vaccines," said Dr. Steven Black, MD, of Cincinnati Children's Hospital Medical Center and lead author of the immune response study. If confirmed, the findings could support the preferential use of high-dose flu vaccine or vaccines containing adjuvants to boost immune response in the elderly, in an attempt to counteract the apparent effect, the study authors wrote.
A high-dose flu vaccine is approved for adults 65 and older in the U.S., as are several standard-dose vaccines. Adjuvanted flu vaccines are available in Europe and other countries but have not yet been licensed for use in the U.S. The Centers for Disease Control and Prevention recommends that everyone 6 months of age and older get a flu vaccine every season. Seniors are at particular risk for serious illness and complications from flu, including death.
In the other new study, conducted by researchers from Emory University, the authors investigated the possible impact of statin therapy on the effectiveness of flu vaccine at preventing serious respiratory illness. The researchers analyzed data spanning nine flu seasons from 2002 to 2011, including information about flu vaccination, statin prescriptions, and cases of medically attended, acute respiratory illness among nearly 140,000 people enrolled in a large managed care organization in Georgia.
"What we found was a potential signal that the effectiveness of flu vaccine in older people may be compromised somewhat if they are on statins, compared to those who are not on statins," said Saad B. Omer, MBBS, MPH, PhD, of Emory University and lead author of the vaccine effectiveness study, which was financially supported by Emory and the National Institute of Allergy and Infectious Diseases.
After adjusting for various factors, the Emory researchers observed that vaccine effectiveness for preventing serious respiratory illness was lower among patients taking statins compared to patients who were not on statins, particularly when flu was widespread in the state. The findings have potential implications for guidelines regarding statin use in older adults around the time of vaccination, but additional studies, including research examining laboratory-confirmed cases of flu, are needed first to provide more guidance, the study authors noted.
The results from both new studies are biologically plausible and raise important questions, but the findings should not yet affect how physicians care for their patients, according to a related editorial commentary by Robert L. Atmar, MD, and Wendy A. Keitel, MD, of Baylor College of Medicine in Houston.
"Instead, the results of these studies should be viewed as hypothesis-generating and should prompt further investigations into whether statins reduce inactivated influenza vaccine immunogenicity and, if so, the mechanisms by which immune responses and associated vaccine effectiveness are adversely affected," the commentary authors wrote. The commentary accompanies the two studies in The Journal of Infectious Diseases.
Fast Facts
- Statins are used by more than 40 percent of the U.S. population over the age of 65, according to the Centers of Disease Control and Prevention.
- In one study of flu vaccine recipients older than 65, statin users had a significantly reduced immune response to flu vaccination, compared to those not taking statins.
- In another study, vaccine effectiveness at preventing serious respiratory illness was lower among patients taking statins compared to patients who were not on statins.
- Additional research is needed to confirm the findings from both studies before potential changes in clinical practice are warranted.
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Editor's Note: The study authors' affiliations, acknowledgments, and disclosures of financial support and potential conflicts of interests are available in the articles. The articles and a related editorial commentary are embargoed until 12:01 a.m. EDT on Thursday, Oct. 29. These pre-publication links are for media access only:
Influence of Statins on Influenza Vaccine Response in Elderly Individuals http://www.oxfordjournals.org/our_journals/jid/prpaper.pdf
Impact of Statins on Influenza Vaccine Effectiveness Against Medically Attended Acute Respiratory Illness http://oxfordjournals.org/our_journals/jid/prpaper2.pdf
Influenza Vaccination of Patients Receiving Statins: Where Do We Go From Here? http://oxfordjournals.org/our_journals/jid/preditorial.pdf
Published continuously since 1904, The Journal of Infectious Diseases is the premier global journal for original research on infectious diseases. The editors welcome major articles and brief reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. The journal is an official publication of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing nearly 10,000 physicians and scientists who specialize in infectious diseases. For more information, visit http://www.idsociety.org. Follow IDSA on Facebook and Twitter.
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The Journal of Infectious Diseases